Meclofenamic acid

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Meclofenamic acid
Meclofenamic acid.png
Systematic (IUPAC) name
2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Clinical data
Trade names Meclomen
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
Identifiers
CAS Registry Number 644-62-2
ATC code M01AG04 M02AA18
PubChem CID: 4037
IUPHAR/BPS 7219
DrugBank DB00939
ChemSpider 3897
UNII 48I5LU4ZWD YesY
KEGG D02341
ChEBI CHEBI:6710
ChEMBL CHEMBL509 YesY
Chemical data
Formula C14H11Cl2NO2
Molecular mass 296.14864 g/mol

Meclofenamic acid (brand Meclomen) is a drug used for joint, muscular pain, arthritis and dysmenorrhea.[1] It is a member of the NSAID class of drugs and was approved by the FDA in 1980. It inhibits the synthesis of prostaglandins.[2]

Use in horses[edit]

Meclofenamic acid is sold under the trade name "Arquel" for use in horses, and is administered as an oral granual form at a dose of 2.2 mg/kg/day.[3] It has a relatively slow onset of action, taking 36-48 hours for full effect,[4] and is most useful for treatment of chronic musculoskeletal disease.[5] It has been found to be beneficial for the treatment of navicular syndrome, laminitis, and osteoarthritis,[4] in some cases having a more profound effect than the commonly-used NSAID phenylbutazone.[6] However, due to cost, it is not routinely used in practice. Toxicity due to excessive dosage is similar to that of phenylbutazone, including depression, anorexia, weight loss, edema, diarrhea, oral ulceration, and decreased hematocrit.[6]

References[edit]

  1. ^ http://www.medicinenet.com/meclofenamate/article.htm
  2. ^ Syed MM, Parekh AB, Tomita T (December 1990). "Receptors involved in mechanical responses to catecholamines in the circular muscle of guinea-pig stomach treated with meclofenamate". British Journal of Pharmacology 101 (4): 809–14. doi:10.1111/j.1476-5381.1990.tb14162.x. PMC 1917864. PMID 1982230. 
  3. ^ McIlwraith CW, Frisbie DD, Kawcak CE. Nonsteroidal Anti-Inflammatory Drugs. Proc. AAEP 2001 (47): 182-187.
  4. ^ a b Cotter GH, Riley WF, Beck CC, Coppock RW. Arquel (Cl- 1583). A new nonsteroidal anti-inflammatory drug for horses, in Proceedings. Am Assoc Equine Practnr 1973;19: 81–90.
  5. ^ Snow DH, Baxter P, Whiting B. The pharmacokinetics of meclofenamic acid in the horse. J Vet Pharmacol Ther 1981; 4:147–156.
  6. ^ a b Lees P, Higgins AJ. Clinical pharmacology in therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 1985;17:83–96.