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Meclonazepam structure.svg
Clinical data
ATC code
  • none
Legal status
Legal status
CAS Number
PubChem CID
Chemical and physical data
Formula C16H12ClN3O3
Molar mass 329.74 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Meclonazepam[1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam.[2] It has sedative and anxiolytic actions like those of other benzodiazepines,[3] and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.[4]

Meclonazepam was never used as medicine and instead appeared online as a designer drug.[5][6]

Legal Issues[edit]

United Kingdom[edit]

In the UK, meclonazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.[7]

See also[edit]


  1. ^ U.S. Patent 4,031,078
  2. ^ The Lundbeck Institute. "Meclonazepam". Psychotropics. Lundbeck. 
  3. ^ Ansseau, M.; Doumont, A.; Thiry, D.; Von Frenckell, R.; Collard, J. (1985). "Initial study of methylclonazepam in generalized anxiety disorder. Evidence for greater power in the cross-over design". Psychopharmacology. 87 (2): 130–135. PMID 3931136. doi:10.1007/bf00431795. 
  4. ^ O'Boyle, C.; Lambe, R.; Darragh, A. (1985). "Central Effects in Man of the Novel Schistosomicidal Benzodiazepine Meclonazepam". European Journal of Clinical Pharmacology. 29 (1): 105–108. PMID 4054198. doi:10.1007/bf00547377. 
  5. ^ Markus R. Meyer; Madeleine Pettersson Bergstrand; Anders Helander; Olof Beck (May 2016). "Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes". Analytical and Bioanalytical Chemistry. 408 (13): 3571–3591. PMID 27071765. doi:10.1007/s00216-016-9439-6. 
  6. ^ Pettersson Bergstrand M, Helander A, Hansson T, Beck O (2016). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Test Anal. PMID 27366870. doi:10.1002/dta.2003. 
  7. ^ "The Misuse of Drugs Act 1971 (Amendment) Order 2017". 

Further reading[edit]

  • Abdul-Ghani, R. A.; Loutfy, N.; Hassan, A. (2009). "Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use". Parasitology Research. 105 (4): 899–906. PMID 19588166. doi:10.1007/s00436-009-1546-2.