Medora may refer to:
In the United States:
- Medora, Illinois
- Medora, Indiana
- Medora, Kansas
- Medora, Louisville, Kentucky
- Medora, North Dakota
- Medora Site, a precolumbian archaeological site in West Baton Rouge Parish, Louisiana
- Medora, Wisconsin, the fictional setting of Aliens in America
- Medora, heroine of Byron's poem The Corsair and Verdi's opera Il corsaro
- Elizabeth Medora Leigh, daughter of Augusta Leigh and possible daughter of Lord Byron
- Medora Vallambrosa, Marquise de Mores (Medora von Hoffman), wife of the Marquis de Mores and namesake of Medora, North Dakota
- John Medora, songwriter and record producer
- Medora (film), 2013 documentary by Andrew Cohn, Davy Rothbart about a small-town basketball team, the Medora Hornets
- Medora (horse), a British Thoroughbred racehorse
- Medora, a brand of ayurvedic weight loss medication marketed in India.
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