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Megavoltage X-rays are produced by linear accelerators ("linacs") operating at voltages in excess of 1000 kV (1 MV) range, and therefore have an energy in the MeV range (see external beam radiotherapy for an explanation of the maximum and mean energies as a function of voltage). They are used in medicine in external beam radiotherapy to treat neoplasms, cancer and tumors. Beams with the voltage range of 4-25 MV are used to treat deeply buried cancers because radiation oncologists find that they penetrate well to deep sites within the body. Lower energy x-rays, called orthovoltage X-rays, are used to treat more superficial cancers.
For instance, in one particular technique of prostate radiotherapy, a patient will be treated with 5 radiation beams of 15 MV X-rays. While the beams will point into the patient from different angles, all the beams will be pointed towards one point or centre in the prostate (so called an isocentric technique). In this way the linac can rotate around the patient who does not need to move. In fact, patient motion is a source of positioning error which a radiation therapist tries to eliminate.
By crossing multiple beams, the radiation dose delivered internally in the prostate is much higher (~70-78 Gy) than the radiation dose delivered on the entry and exit tracks of each individual beam (~40 Gy). This lower dose outside the prostate rarely leads to side effects or any detectable change.