Meherpur District has an area of 716.08 km2. It is bounded by Kushtia District and West Bengal of India on the north, Chuadanga District and West Bengal on the south, Chuadanga and Kushtia districts on the east, and West Bengal on the west.
Meherpur is a historical district of Bangladesh for the fact that the Proclamation of Independence was solemnly made at the village Baidyanathtola (now Mujibnagar), on 17 April 1971 of this district. The first provisional government of Bangladesh was born here under the leadership of Tajuddin Ahmed. After that day on 18 April 1971, the Pak army killed 8 persons at village Amjhupi.