Melanocortin 3 receptor

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Melanocortin 3 receptor
Symbols MC3R ; BMIQ9; MC3; MC3-R; OB20; OQTL
External IDs OMIM155540 MGI96929 HomoloGene7412 IUPHAR: 284 ChEMBL: 4644 GeneCards: MC3R Gene
RNA expression pattern
PBB GE MC3R 221442 at tn.png
More reference expression data
Species Human Mouse
Entrez 4159 17201
Ensembl ENSG00000124089 ENSMUSG00000038537
UniProt P41968 P33033
RefSeq (mRNA) NM_019888 NM_008561
RefSeq (protein) NP_063941 NP_032587
Location (UCSC) Chr 20:
56.25 – 56.25 Mb
Chr 2:
172.25 – 172.25 Mb
PubMed search [1] [2]

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.[1][2]

This gene encodes MC3, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.[2]

See also[edit]


  1. ^ Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (May 1993). "Molecular cloning of a novel melanocortin receptor". J Biol Chem 268 (11): 8246–50. PMID 8463333. 
  2. ^ a b "Entrez Gene: MC3R melanocortin 3 receptor". 

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.