Melanotransferrin

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MELTF
Identifiers
AliasesMELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDsOMIM: 155750 MGI: 1353421 HomoloGene: 4335 GeneCards: MELTF
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MELTF
Genomic location for MELTF
Band3q29Start196,988,621 bp[1]
End197,029,817 bp[1]
RNA expression pattern
PBB GE MFI2 220043 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005929
NM_033316

NM_013900

RefSeq (protein)

NP_005920
NP_201573

NP_038928

Location (UCSC)Chr 3: 196.99 – 197.03 MbChr 16: 31.88 – 31.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy. }}

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163975 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022780 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.