Melanotransferrin

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MELTF
Identifiers
Aliases MELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDs MGI: 1353421 HomoloGene: 4335 GeneCards: 4241
RNA expression pattern
PBB GE MFI2 220043 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005929
NM_033316

NM_013900

RefSeq (protein)

NP_005920.2
NP_201573.1

NP_038928.1

Location (UCSC) Chr 3: 196.99 – 197.03 Mb Chr 16: 31.88 – 31.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[1] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.