Melkersson–Rosenthal syndrome

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Melkersson–Rosenthal syndrome
Classification and external resources
Specialty neurology
ICD-10 G51.2
ICD-9-CM 351.8
OMIM 155900
DiseasesDB 31963
eMedicine derm/72
MeSH D008556

Melkersson–Rosenthal syndrome (also termed "Miescher-Melkersson-Rosenthal syndrome"),[1] is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip), and the development of folds and furrows in the tongue.[2]:799 Onset is in childhood or early adolescence. After recurrent attacks (ranging from days to years in between), swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson–Rosenthal syndrome is unknown, but there may be a genetic predisposition. It has been noted to be especially prevalent among certain ethnic groups in Bolivia. It can be symptomatic of Crohn's disease or sarcoidosis.[citation needed]


Treatment is symptomatic and may include nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids to reduce swelling, antibiotics and immunosuppressants. Surgery may be indicated to relieve pressure on the facial nerves and reduce swelling, but its efficacy is uncertain. Massage and electrical stimulation may also be prescribed.[citation needed]


Melkersson–Rosenthal syndrome may recur intermittently after its first appearance. It can become a chronic disorder. Follow-up care should exclude the development of Crohn's disease or sarcoidosis.[citation needed]


The condition is named for Ernst Melkersson and Curt Rosenthal.[3][4][5]


The NINDS supports research on neurological disorders such as Melkersson–Rosenthal syndrome. Much of this research is aimed at increasing knowledge of these disorders and finding ways to treat, prevent, and ultimately cure them.

See also[edit]


  1. ^  Missing or empty |title= (help)
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  3. ^ synd/9 at Who Named It?
  4. ^ Melkersson, E. (1928). "Ett fall av recidiverande facialispares i samband med ett angioneurotiskt ödem". Hygiea. Stockholm. 90: 737–741. 
  5. ^ Rosenthal, C. (1931). "Klinisch-erbbiologischer Beitrag zur Konstitutionspathologie. Gemeinsames Auftreten von Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien". Zeitschrift für die gesamte Neurologie und Psychiatrie. 131: 475–501. doi:10.1007/bf02865984.