Membrane topology

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Topology of a membrane protein refers to location of N-terminus of the protein at the cytosolic or non-cytosolic sides of the biological membrane occupied by the protein.[1] For example, topology of a protein attached to the cell plasma membrane indicates location of its N-terminus at the cytoplasmic or extracellular side of the membrane. Every individual transmembrane segment of a protein also has topology, depending on location of its N-terminus on the inner or outer side of the membrane. There are several databases which provide topologies of membrane proteins including Uniprot, TOPDB[2][3] and ExTopoDB.[4] There are several computational methods for predicting transmembrane domains, both for helices and β-barrels.[5][6]