Mephenesin

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Mephenesin
Mephenesin.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
ECHA InfoCard 100.000.389
Chemical and physical data
Formula C10H14O3
Molar mass 182.216 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.[1] Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries.[2] Its use has largely been replaced by the related drug methocarbamol, which is better absorbed[3]

Mephenesin may be an NMDA receptor antagonist.[4]

See also[edit]

External links[edit]

  • Bachmeyer C, Blum L, Fléchet M, Duriez P, Cabane J, Imbert J (1996). "[Severe contact dermatitis caused by mephenesin]". Ann Dermatol Venereol. 123 (3): 185–7. PMID 8761781. 
  • Ono H, Nakamura T, Ito H, Oka J, Fukuda H (1987). "Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin". Gen Pharmacol. 18 (1): 57–9. doi:10.1016/0306-3623(87)90170-4. PMID 3557053. 

References[edit]

  1. ^ "Mephenesin". MIMS. 
  2. ^ "Mephenesin". Drugs.com. 
  3. ^ Huf, Ernst; et al. "Comparative Plasma Levels of Mephenesin, Mephenesin Carbamate and Methocarbamol". Experimental Biology & Medicine. Retrieved 8 January 2014. 
  4. ^ Keshavarz M, Showraki A, Emamghoreishi M (2013). "Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice". Iran J Med Sci. 38 (2): 116–21. PMC 3700057Freely accessible. PMID 23825891.