Mepivacaine

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Mepivacaine
Mepivacaine.png
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a603026
Pregnancy
category
  • C, use w/ caution, may cause fetal bradycardia
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.002.313
Chemical and physical data
Formula C15H22N2O
Molar mass 246.348 g/mol
3D model (Jmol)
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Mepivacaine /mɛˈpɪvəkn/ is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.

Mepivacaine became available in the United States in the 1960s.

Mepivacaine is used in any infiltration and regional anesthesia.

It is supplied as the hydrochloride salt of the racemate, [2] which consists of R(-)-mepivacaine and S(+)-mepivacaine in equal proportions. These two enantiomers have markedly different pharmacokinetic properties. [3]

References[edit]

  1. ^ Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal. 12 (1): E60–4. PMID 17195831. 
  2. ^ Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9. PMID 8989005. doi:10.1097/00000539-199701000-00016. 
  3. ^ http://journals.lww.com/anesthesia-analgesia/Fulltext/1997/01000/Pharmacokinetics_of_the_Enantiomers_of_Mepivacaine.16.aspx

External links[edit]