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Merck may refer to:
- Merck & Co., Inc. (Merck Sharp & Dohme outside North America), an American pharmaceutical company, one of the world's largest pharmaceutical companies. It was created after World War I from assets forfeited by Merck KGaA, though the two are not associated.
- Merck KGaA, (EMD Chemicals in the United States and Canada), a German chemical and pharmaceutical company
- Merck Serono (EMD Serono in North America), a pharmaceutical division of Merck KGaA
- Merck Manual of Diagnosis and Therapy, a medical textbook published by Merck & Co.
- The Merck Index, an encyclopedia of chemistry, formerly published by Merck & Co. and now by the Royal Society of Chemistry
- Merck Veterinary Manual, a reference manual of animal health care published by Merck & Co. and Merial Limited
- Merck family, original owners of the chemical companies above
- Ernst Merck (1811–1863), German businessman and politician
- George W. Merck (1894–1957), American president of Merck & Co.
- Heinrich Emanuel Merck (1794–1855), German apothecary whose descendants were the founders of Merck chemical companies
- Johann Heinrich Merck (1741–1791), German author and critic
- William Merck (1852–1925), British commissioner in India
- Merck Finck & Co., a German private bank
- Johann-Heinrich-Merck-Preis, a literary prize of Hesse, Germany
- Merck Records, an IDM and experimental hip hop record label based in Miami, Florida, USA
- Merck-Saint-Liévin, a commune in the Pas-de-Calais department, France
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