Mercury(II) reductase

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mercury (II) reductase
EC number
CAS number 67880-93-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mercury(II) reductase (EC is an enzyme that catalyzes the chemical reaction

Hg + NADP+ + H+ \rightleftharpoons Hg2+ + NADPH

The 3 substrates of this enzyme are Hg, NADP+, and H+, whereas its two products are Hg2+ and NADPH.


This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor.


The systematic name of this enzyme class is Hg:NADP+ oxidoreductase. Other names in common use include mercuric reductase, mercurate(II) reductase, mercuric ion reductase, mercury reductase, reduced NADP+:mercuric ion oxidoreductase, and mer A.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ZK7 and 1ZX9. A low resolution (>3.9 Å) was solved in 1991.[1]


  1. ^ Schiering N, Kabsch W, Moore MJ, Distefano MD, Walsh CT, Pai EF (July 1991). "Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607". Nature 352 (6331): 168–72. doi:10.1038/352168a0. PMID 2067577. 

Further reading[edit]

  • Fox B, Walsh CT (1982). "Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide". J. Biol. Chem. 257 (5): 2498–503. PMID 6277900. 
  • Fox BS, Walsh CT (1983). "Mercuric reductase - homology to glutathione-reductase and lipoamide dehydrogenase - iodoacetamide alkylation and sequence of the active-site peptide". Biochemistry 22 (17): 4082–4088. doi:10.1021/bi00286a014. PMID 6412751.