|Grey's Anatomy character|
|First appearance||"A Hard Day's Night"
1x01, March 27, 2005
|Created by||Shonda Rhimes|
|Portrayed by||Ellen Pompeo (adult)
Nicolette Collier (young)
Claire Geare (age 3)
Aria Leabu (Season 11 flashbacks)
|Full name||Meredith Grey|
The girl in the bar
The Perfect Twelve-year-old
The Good Grey
|Occupation||Chief of General Surgery at Grey Sloan Memorial Hospital (formerly known as Seattle Grace Hospital)
Board Director at Grey Sloan Memorial Hospital
|Title||Head of General Surgery
|Family||Ellis Grey (mother, deceased)
Thatcher Grey (father)
Lexie Grey (paternal half-sister)
Molly Thompson (paternal half-sister)
Maggie Pierce (maternal half-sister)
Laura Thompson (half-niece)
|Spouse(s)||Derek Shepherd (m. 2009; d. 2015)|
|Significant other(s)||George O'Malley
|Children||Zola Shepherd (daughter)
Derek Bailey Shepherd (son)
Ellis Shepherd (daughter)
Meredith Grey, M.D. is a fictional character from the hit medical drama television series Grey's Anatomy, which airs on the American Broadcasting Company (ABC) in the United States. The character was created by series' producer Shonda Rhimes, and is portrayed by actress Ellen Pompeo. Meredith is the series' protagonist, and was introduced as a surgical intern at the fictional Seattle Grace Hospital (later Seattle Grace-Mercy West, and afterwards Grey Sloan Memorial), eventually obtaining the position of a resident, and later the position of an attending, and in 2015, attaining the Chief of General Surgery position. As the daughter of world-renowned surgeon Ellis Grey, Meredith struggles with the everyday life of being in a competitive profession, maintaining the relationship with her one-night stand and eventual husband Derek Shepherd (deceased), her motherhood, and her friendships with her colleagues.
Meredith is the narrator of the show and serves as the focal point for most episodes. Pompeo's connection with Patrick Dempsey (Derek Shepherd) is acclaimed as a high point of the series. Rhimes has characterized Meredith as not believing in good or bad, but instead doing what she thinks is right. Grey has been positively received by television critics, with Alessandra Stanley of The New York Times referring to her as "the heroine of Grey's Anatomy". News of Pompeo leaving arose when it was made clear that her contract ended after the eighth season, and whether or not she would return to the series after her contract expires has been the centre of media speculation ever since. In 2016, Pompeo re-negotiated her contract and signed up for the thirteenth season of the show.
Pompeo's performance has been well received throughout the show and the character has gained widespread popularity worldwide. Pompeo has been nominated for multiple awards for her portrayal of the character in the long running ABC medical drama including Satellite Award for Best Actress and multiple nominations at the People's Choice Awards for Best Actress winning at 39th People's Choice Awards in 2013 and again in 2015 at 41st People's Choice Awards, Pompeo has also received a Best Performance by an Actress in a Drama Series nomination at the 64th Golden Globe Awards.
Dr. Meredith Grey is the daughter of world-renowned surgeon Ellis Grey, who suffers from Alzheimer's disease. She is a graduate of Dartmouth College. The night before Grey's internship begins, she has a one-night stand with Derek Shepherd (Patrick Dempsey), a stranger she meets at a bar. She discovers the next day that he is the recently-hired attending and new head of neurosurgery at her new workplace, Seattle Grace Hospital. Grey is assigned to work under resident Miranda Bailey (Chandra Wilson), and befriends her fellow interns, George O'Malley (T.R. Knight), Izzie Stevens (Katherine Heigl), Cristina Yang (Sandra Oh) and Alex Karev (Justin Chambers). Grey initially resists Shepherd's advances, but they eventually begin a relationship. She is surprised by the arrival of Addison Montgomery (Kate Walsh), Shepherd's wife, having been unaware that he was married. Shepherd struggles to choose between the two, but ultimately returns to Montgomery. Grey is devastated and turns to searching for her father, Thatcher, though their brief reunion fails to give her any closure regarding her childhood. She learns that her father remarried and had two more daughters, which is why he never fought for her. Grey has a series of one-night stands, including one with O'Malley, who is in love with her. When she cries in the middle of their encounter, their friendship temporarily ends. Grey embarks on a relationship with veterinarian Finn Dandridge (Chris O'Donnell), but it comes to a close when she reunites with Shepherd.
Her mother experiences a completely lucid day, and expresses her great disappointment at how ordinary Grey has turned out to be. Following a ferryboat accident, Grey is knocked into the water and has to be rescued by Shepherd. She flatlines at the hospital, and awakens in an "afterlife", where she interacts with deceased former acquaintances. Ellis dies in the interim, and Grey meets with her mother, who tells her that she is anything but ordinary and urges her to wake up. Grey is subsequently resuscitated. She is promoted to a resident, as her half-sister Lexie Grey (Chyler Leigh), begins working at Seattle Grace Hospital as an intern. Grey initially rejects Lexie's attempts to form a relationship, but slowly softens towards her. Shepherd pushes Grey to make a greater commitment to their relationship than she feels able to, and the two break up once more. He begins dating a nurse, Rose, and Grey sees a therapist, Dr. Wyatt (Amy Madigan), to seek happiness. She initiates a neurosurgical clinical trial, enlisting Shepherd as a consulting neurosurgeon. The trial fails repeatedly, but the final patient they treat survives, which leads them to reuniting and moving in together. Shepherd loses his confidence after a minor mistake in the initial operation on a pregnant patient started a chain of events which ended with the patient's death and faced a malpractice lawsuit, leading to him taking a sabbatical and pushing everyone, including Grey, away. When Stevens is diagnosed with stage four metastatic melanoma, Grey convinces Shepherd to return to operate on her as he was one of the few neurosurgeons able to perform the surgery. He agrees to perform the surgery, and later proposes to Grey in the hospital elevator. Stevens begins to plan the "perfect wedding" for a reluctant Grey, but when, on their wedding day, Shepherd discovers that Stevens has a second brain tumor, the couple let her and Karev marry instead.
Grey and Shepherd marry by writing their wedding vows on a post-it note. Having become a heavy drinker following Susan's death, Thatcher experiences liver failure. For Lexie's sake, Grey agrees to donate part of her liver to him. Thereafter, she discovers she is pregnant soon before a hospital shooting, endangering Shepherd. In the midst of the crisis, Grey miscarries the baby. She learns that she has a "hostile uterus", which leads her to consider her other possible genetic flaws. Shepherd, worried about the possibility that she will develop Alzheimer's, initiates a clinical trial hoping to cure the disease. Grey opts to work on the trial, with Shepherd. When the chief of surgery, Richard Webber (James Pickens Jr.)'s wife, Adele, is diagnosed with Alzheimer's, she receives a spot on Shepherd's trial. Grey tampers with the drugs so that Adele does not receive the placebo. She and Shepherd decide to adopt Zola, an orphaned baby from Malawi, and make their marriage official. When the truth about Grey's tampering comes out, however, a furious Shepherd tells her he cannot raise a child with her. Grey is fired, and tries to conceal both this and her marital separation from the adoption counselor. Although Webber steps down as chief of surgery and takes the blame for the trial tampering to protect Grey, Zola is taken away. She and Shepherd reconcile and fight to get Zola back, eventually having her returned to them. Meanwhile, Meredith experiences several traumatic events, such as an ambulance accident with Alex Karev. As her last year of residency is coming to a close, the residents travel around the country, searching for the best jobs in their specialties. In order to finish their residency, the residents must take the medical boards, and Grey passes them successfully. She decides to take a job offer at The Brigham and Women's Hospital, and is subsequently involved in an aviation accident, killing Lexie, eventually mark and leaving her and her co-workers stranded.
Following their rescue, Grey becomes an attending general surgeon at Seattle Grace, which had since merged with Mercy West to become Seattle Grace Mercy West. Her newfound attitude and sarcasm leads to her being dubbed "Medusa" by the hospital's new batch of interns. In mid-season, Grey becomes pregnant for the second time. In the aftermath of the plane accident, the hospital is sued and eventually found guilty of negligence. Each victim including Shepherd, Yang, Robbins, and herself must receive $15 million of compensation, which leads the hospital to a near bankruptcy as the insurance company refuses to pay due to a loophole. Those doctors and Callie Torres (Sara Ramirez) buy the hospital with the help of the Harper Avery Foundation to prevent it from closing, and each become members of the new directing board. She asks Bailey to perform gene mapping on her to finally know whether she has Alzheimer's genes like her mother or not and she tests positive for more than one of the genetic markers for the disease.
During this time, Meredith discovers she is pregnant again and she gives birth to a son. The baby is delivered via C-section during a storm because it was not in the correct position. While stitching Meredith up, the obstetrician who operated on Meredith is called away to another patient and intern Shane Ross completes the stitching. When blood begins to appear from everywhere, Meredith diagnoses herself in as being in DIC. Bailey performs a spleen removal, which saves Meredith's life. In return, Derek and Meredith name their son Bailey.
As a spouse, surgeon, and mother, Meredith has cited a number times that she did not want to be like either of her parents: her father had followed her mother around and ended up leaving as she valued her career over her family while her mother won two Harper Avery Awards but emotionally neglected her, resulting in her "dark and twisty" attitude towards life. She and Cristina drift apart as they realize that they now have different values and career paths. After being snubbed by Cristina for failing to keep up with the medical science while on maternity leave, Meredith calls Cristina out on her actions, stating that it was not fair for her to ignore those who did not value the same things she did. Cristina realizes that she has to leave Seattle before things deteriorate and eventually moves to Switzerland take up a job offer from Dr. Preston Burke, her former attending and mentor, who was looking for a replacement at a research hospital he was running. Meanwhile, Meredith and Derek come to an agreement that he, having already established his career and reputation, would take a step back to take care of the children and allow her to shine.
Meredith and Derek's marriage becomes strained when Derek goes against his promise and accepts an offer from the President to participate in the Brain Mapping Initiative, which gradually consumed his time. He receives an offer to head the project itself in Washington D.C., meaning that he would have to be based there permanently, but she puts her foot down as she did not want to uproot their young family to move across the country. They begin a series of on-and-off arguments and "cold wars" over their careers. Derek accepts the job in the heat of the moment and promptly leaves for Washington D.C. During a phone call with Meredith, they agree to work things out after she tells him that she did not want them to become "one of those couples" who ended things and he reciprocates, saying that he missed her. She privately admits to Alex that she realized that she could live independently of Derek but chose not to.
Meredith finds out she has a half sister called Maggie Pierce who is now working in Grey Sloan Memorial. Meredith thinks she would have remembered if her mother was pregnant and thinks Maggie is lying until she finds a hospital document confirming the revelation. Meredith tries to piece together her relationship with her mother and half sister by going through old videos of her mother. She eventually recovers her repressed memories of the pregnancy when she views her mother's diary and has a change of heart, choosing to accept her and begin building a relationship.
Meredith is widowed when Derek is a victim in a car accident and taken to Dillard Medical Center which did not have Level I trauma center status and was understaffed. He was on his way to the airport for his final trip to Washington D.C. to hand in his final report and official resignation letter when he took a shortcut and stopped to help victims of a multiple vehicle accident. The doctors at Dillard fail to recognize his head injury in time. Derek becomes brain dead, and police arrive at Derek and Meredith's residence to notify her that Derek has been in an accident. Meredith begins to imagine arriving at the hospital and seeing Derek in stable condition, alive and alert. The scene then switches to reality with Meredith arriving at the hospital to see Derek in critical condition, where she spends time with him and then consents to remove him from life support, shortly before she's hit with the first waves of morning sickness. She tells Penny, the intern who was assigned to Derek, that every doctor has "that one" patient who dies on their watch and haunts them forever and "that one will make you work harder, and they make you better."
After Derek's death, Meredith returns to Grey Sloan Memorial to inform the others of his passing. Following the funeral service, Meredith impulsively packs up her belongings and leaves with the children to San Diego. Months pass by while her friends and family are unaware of her whereabouts. Eventually, we are shown the parallels between Meredith and Ellis' lives. Both have lost the love of their life, both run away from Seattle following their loss, and both eventually give birth to a daughter. We are again reminded that "the carousel never stops turning." Meredith names her newborn daughter after her mother, Ellis. Although still grieving over Derek, Meredith returns to Seattle with the children and later becomes chief of general surgery. She sells the "dream house" as it no longer felt like home without her husband. She moves back to her mother's house and now lives there with Maggie Pierce and Amelia Shepherd. Meredith hosts a dinner party and at the party Callie brings Penny as a date. Later at the event she finds out Penny (Derek's doctor) will be joining her at Grey Sloan Memorial. She finds herself in between her sister-in-law Amelia and long-time colleague Callie as Amelia was still grieving over her brother's death and was determined to make Penny's experience miserable. In the episode "My Next Life" she has a flashback of her first surgery with Derek when their former patient Katie Bryce returns with a brain aneurysm and is coincidentally operated on by Amelia. She starts seeing Nathan Riggs by season 13, although their relationship is complicated by the fact that Maggie confesses to Meredith that she has feelings for Riggs.
Casting and creation
Pompeo discovered Grey's Anatomy after a year of doing nothing but reading scripts looking for the project that suited her best. While casting actresses for the part of Meredith Grey, series' creator Shonda Rhimes said: "I kept saying we need a girl like that girl from Moonlight Mile, and after a while, they were like, 'We think we can get that girl from Moonlight Mile.' I spent time with her and got to know her, and then we started casting for the men." She reported that Grey was not an easy role to cast. Rhimes was informed that the actress in question was Pompeo, who had a deal in place with ABC, having previously tested for a pilot show on the network. It has been speculated that Pompeo was the first character to be cast, but when asked, she said she did not know of this. When asked of how she created Pompeo's character, Rhimes said:
|“||"[I was] in my pajamas at home, which is where I spent a lot of time writing. I kept asking myself, 'What kind of woman should the heroine be?' I thought she should be someone who had made some big mistakes. As it turns out, Meredith also has another problem: She is trying to live up to her mother's renowned career in surgery. Meredith is the daughter of a mother who basically never spent any time with her—the daughter of a mother who now has Alzheimer's and doesn't even remember her."||”|
Pompeo was cast as the program's titular character, described by Mary McNamara of the Los Angeles Times as "a prickly, independent sort whose ambition, and ambivalence, is fueled by the fact that her mother was a gifted surgeon and now suffers from Alzheimer's." Grey also serves as the show's narrator, and as such was likened in early reviews to Carrie Bradshaw (Sarah Jessica Parker), the narrator and protagonist of Sex and the City. After her initial contract with Grey's Anatomy expired, Pompeo negotiated a new one, in which she would be paid US$200,000 per episode, making her the highest-paid cast member on the show. In 2012, Forbes recognized Pompeo as the eighth highest-paid actress on television, with a salary of US$275,000 per episode for her role on Grey's Anatomy.
Pompeo's second contract with Grey's Anatomy expired after the eighth season, and speculation arose that she would be leaving after this. In September 2011, Pompeo reported that she is open to the idea of extending her contract, if invited. She told TV Guide: "I would never turn up my nose at [Grey's Anatomy]. As long as the stories are honest and truthful, and Patrick [Dempsey] and I feel there is material for us to be passionate about, it still beats a 9-to-5 job any day. If I hear from the fans that they want us to keep going, then I would continue because we owe them everything." E! Online reported in May 2012, that Pompeo, as well as all original cast members have signed on for two more years. With the Huffington Post's announcement of season nine having officially been renewed, the contract is set into place for Pompeo to return.
Pompeo's contract expired again at the end of the twelfth season. She signed a new contract to keep her in the starring role on the series for thirteenth season. According to a report in Deadline.com, Pompeo was earning $300,000 per episode under the new deal.
Grey is the protagonist and focal point of the series. She has been called "intelligent, compassionate, hard-working, oftentimes outspoken, easily distracted, and indecisive" by Grey's Anatomy executives. Pompeo says she is unaware if her character knows how to have fun, adding: "All of my scenes with [Dempsey] are the same—we're either breaking up or having sex." Her personality has evolved over the past few seasons from depressed, to happy and "fixed". Pompeo said to Good Morning America, "I am so incredibly lucky to have Patrick [Dempsey], to have the chemistry that we do, we have an amazing relationship, and it's like any other relationship, you have your ups and downs. But we work it out, and we've found a way to do this for this long and still get along, and make it work and believe in what we're doing." Pompeo told Entertainment Weekly: "It's awkward with Patrick [Dempsey] because he's like my brother. As soon as the camera is off, I'm like, 'Is your hand on my butt?' But there are millions of girls who have been waiting for this, so I feel an obligation to the fans." Rhimes used the dog "Doc", which Meredith and Derek shared, as a metaphor of their relationship during the second season. She characterizes Grey as doing what she thinks is right:
|“||Meredith is the girl who put her hand on a bomb in a body cavity. Meredith is the girl who tried to help a serial killer kill himself, so that he could donate his organs. Meredith—and this is obvious—has a compass that has always led her to shades of grey. She does not believe in black-and-white, she does not believe in good or bad, she does what she thinks is right.||”|
The character had a one-night stand with George O'Malley, in the second season. Series writer Stacy McKee, said of the sexual encounter: "There’s no turning back. There’s nothing George and Meredith can do. The damage is done – things will never be the same. They’ve just changed something important in their lives FOREVER and…they are freaking out." Grey's character development has also been known as an influence on the creation of her half-sister, Lexie Grey. Particularly, it has been made clear that they both share the same motives. McKee offered her thoughts: "Meredith and Lexie both want to succeed. They want to be strong. They want to feel normal. They want, so much, to be whole. But it’s a struggle – a genuine struggle for them. Being hardcore doesn’t come naturally. Sometimes, they have to fake it." Grey's personality has been compared with that of Alex Karev's. Rhimes offered the insight:
"I like to create moments for him and Meredith. Because, in my head, they are very similar people. Even though Karev can be such an ass, even though he’s arrogant, even though he gave O'Malley the Syph. He and Meredith are both lost, both lonely, both former screw-ups who got their acts together. In another lifetime, they would be really good friends. So throughout the season, we watch them pause from time to time to look at each other and see that they are mirrors of one another.— Shonda Rhimes, Grey Matter
Pompeo fights for a truthful storyline for her character—she wants it to be realistic and says you can't always wrap it up in a neat little package. Referring to Grey's tampering with Shepherd's trial, Pompeo said: "Listen, what Meredith did clearly crossed a line. Derek has a right to be pissed." Following the tampering, Rhimes said she believes that Grey and Shepherd are meant to be together and that it in the end, they will end up with each other. Grey's relationship with Cristina Yang, has been looked upon as "sisterhood", and Yang has repeatedly referred to Grey as "her person". This led to the two being dubbed "the twisted sisters". At the conclusion of season three, the duo went on a "honeymoon" together, and Rhimes called it her favorite detail of the finale. Grey has been characterized, by some, as "whiny". Rhimes offered her insight:
|“||I've heard a lot of talk about Meredith being whiny but the truth is, she's got a mom [who died of] Alzheimer's, no other family to speak of, and the man she loves is married. She's pretty freaking lonely, people. She's got a right to get her whine on. So, when she falters, it's partly because she's got nothing to hang on to. As she says in the first episode, she needs a reason to go on, she needs some hope.||”|
Rhimes felt that the 100th episode showed well Meredith's evolution throughout the show from a "dark and twisty girl" to a "happy woman". She said: "She is the thing her mother wished for her. She is extraordinary. Because, to get past the crap of your past? To move on? To let the past go and change? That is extraordinary. To love? Without fear? Without screwing it up? That is extraordinary. It makes me happy to see her happy."
Following the departure of Patrick Dempsey's character, Rhimes was quoted as saying that "...Meredith and the entire Grey’s Anatomy family are about to enter uncharted territory as we head into this new chapter of her life. The possibilities for what may come are endless."  With at least a year left in Pompeo's contract with the show, viewers are sure to witness some of the most difficult times of Meredith's life yet.
The character has received both overwhelmingly positive reviews to weary response from television critics throughout the course of the show. The initial response to the character was positive but as the series progressed Meredith Grey became immensely popular and Pompeo established the character as a critic and fan favorite featuring on a number of Top TV Character lists. The development of the character has been deemed as the highlight of the show. Grey has constantly been defined as "the heroine of Grey's Anatomy". At the time of inception Newsday's Diane Werts praised the character stating, "Like Hugh Laurie's irascible "House" title character, star Ellen Pompeo's newly minted Dr. Grey conveys such substance that you simply can't stop watching." Ellen A. Kim of After Pompeo not receiving an Emmy nomination for her work as Grey, McNamara of the Los Angeles Times suggested that Pompeo, "who has worked very hard and against all narrative odds to make Meredith Grey an interesting character at last" should have received a nomination at the 61st Primetime Emmy Awards. Later, during the twelfth season Western Gazette gave Ellen Pompeo the credit for carrying the show and re-ittirated." (It's) time for Pompeo to finally win an Emmy Award." Tanner Stransky of Entertainment Weekly referred to Grey as the "trusty voice over master" of Grey's Anatomy.
Former television columnist for The Star-Ledger Alan Sepinwall expressed his boredom on the focus given on Grey's relationships storylines while reviewing the second season's finale: "On those occasions when Meredith's not involved in a plot about her love life, I do kind of like her, but those moments are so infrequent compared to her constant angsting over McDreamy -- not to mention all those seemingly unrelated storylines that always turn into a metaphor for that relationship -- that I really, really can't stand her." During the show's third season, the development of the character received negative reviews, with Cristopher Monfette of IGN stating that her storyline has become "some bizarrely under-developed sub-plot about depression and giving Derek a season's worth of reconsidering to do." Also during the third season, Robert Rorke of the New York Post noted the decline in Meredith's role in the show, expressing disappointment: "She used to be the queen of the romantic dilemmas, but lately, she's been a little dopey, what with the endless McDreamy soliloquies." Similarly, Macleans.ca found their storyline in the fourth season overused, "This whole 'Oh I need more time,' but 'Oh, I'm jealous if you look at someone else' angst was tired in the second season, frustrating in the third and now a total channel changer. The will-they-or-won't-they plot doesn't work because they've already been in and out of that relationship too many times. Meredith is a nag and McDreamy is henpecked." On a more positive note, her relationship with Shepherd was included in AOL TV's list of the "Best TV Couples of All Time" and in the same list by TV Guide. During the sixth season the development of the character was praised, Glenn Diaz of BuddyTV commented that "You gotta love Mer when she's gloomy.", in addition to praising Pompeo's performance. In her review of the episode Tainted Obligation she wrote "I felt for Meredith, but after Lexie's heartfelt begging and pleading, I was happy that Mere finally grows up and casts her selfishness aside. Three seasons ago Meredith would never have dreamed of putting Lexie first, and I was proud of her for giving up part of her liver—her offer to get to know her dad was an even bigger milestone." Reviewing the first part of the eighth season, TV Fanatic lauded the character and wrote: "this season belongs to Meredith Grey. She is the heart and soul of the show and has been outstanding. This is a character that used to be so dark and twisty and has now grown into a more mature woman. Ellen Pompeo has been at the top of her game this season."
Wit & Fancy praised the transformation of the character and stated, "Of course Meredith will still make rash decisions like when she took off with Zola, or tampered with the trial but she does things out of love and the kindness of her heart now and not because she is dark and twisty. Considering where Meredith was at the beginning and where she is now, I think she went through a remarkable journey and did more than just growing up, she finally became “all whole and healed“."
Maura O'Malley of Bustle also lauded the development of the character ahead of season 12 saying, "When the series began, Meredith was just a girl sitting in a bar celebrating the exciting next phase of her life. She had graduated medical school, she was starting her residency at a prestigious hospital, and she was simply looking for a no-strings attached, one night stand. What she got instead was a complicated romantic relationship that rivals Romeo and Juliet — but the key is, she wasn't searching for love. Working and learning were — and continue to be — her priorities, while McDreamy was simply an added perk. Hopefully, the new season of Grey's Anatomy will reflect this change in tone, because Meredith is a strong, independent woman — and she will be just fine."
Later in the series, Ellen Pompeo received critical acclaim with numerous critics lauding her portrayal of the character. Reviewing the episode She's Leaving Home CarterMatt called her the "anchor" for Grey's saying, "Throughout, this was an episode completely anchored by Ellen Pompeo, who has done some of her best work ever on the show the past couple of weeks. Tonight, she cried, she fought, and she learned that she was carrying his child." and added that Pompeo is often "ovelooked" saying, "Her subtlety is probably why she is often overlooked." Rick Porter of Zap2it reviewing "How to Save a Life" wrote, "Without Meredith, and without one of Pompeo's strongest performances in her long time on the show, "How to Save a Life" would have run the risk of coming across as a baldly manipulative death episode, the likes of which the show has done several times before. He added. "How to Save a Life" may not be the ideal Emmy-submission episode for Pompeo, considering Meredith is off screen for more than half of it. But it's among the best work she's ever done on the show." USA Today also lauded Pompeo saying, " In some ways, the episode (How to Save a Life) was even more of a showcase for Pompeo. She had some of the more memorable and well-played scenes, from her angry response to the doctor who tries to tell her what her choices are, to her resignation when she realizes she has to comfort and motivate the young doctor whose mistakes cost Derek his life."
The relation between Meredith and Cristina has been acclaimed and been a highlight of the show. Mark Perigard of the Boston Herald considered the friendship to be "the secret core of Grey's". Aisha Harris of Slate called their relation The Best Female Friendship on TV adding that "With those two characters, showrunner Shonda Rhimes and her team of writers created one of the most nuanced and realistic portrayals of female friendship on television." Samantha Highfill of Entertainment Weekly called Cristina and Meredith the best female friends on TV because "they don’t try to be". There’s nothing fake about them, which is a rarity in how female friends are portrayed on television. She further went on to call them 'soulmates', " And even though they’d never dare get sappy enough to say it, they’re soul mates. Margaret Lyons of Vulture (magazine) called the friendship " dream BFF relationship." and the primary focus of the show, "One of the series' calling cards has been its depiction of female friendship and particularly the primacy that friendship enjoyed over romantic relationships." 
|“||"I wanted to create a world in which you felt as if you were watching very real women. Most of the women I saw on TV didn't seem like people I actually knew. They felt like ideas of what women are. They never got to be nasty or competitive or hungry or angry. They were often just the loving wife or the nice friend. But who gets to be the bitch? Who gets to be the three-dimensional woman?" - Rhimes on Cristina-Meredith friendship.||”|
E! at the time of Sandra Oh's exit wrote, "In Grey's Anatomy's 10-year history, the doctor duo has been through a lot together: weddings, deaths, plane crashes, bomb threats, shooting, you name it, they've lived (and danced) through it. " and added, "And with the three words, "You're my person." Cristina Yang and Meredith Grey solidified their status as the small screen's best best friends ever." Marama Whyte of Hypable wrote, "Critically, the key relationship in Meredith’s life was not her romance with Derek Shepherd, but her passionate, indestructible, absolutely enviable friendship with Cristina. Talk about relationship goals; who wants McDreamy when Cristina Yang could be your person. These two were the real powerhouse, and Shonda Rhimes didn’t shy away from making the audience remember this. Derek was the love of her life, but Cristina was her soul mate. More than anyone else, Cristina challenged Meredith, was honest with her, and inspired her. For these reasons, it was Cristina who was constantly the source of Meredith’s character development, not Derek."
Pompeo's character has also been used to define the image a strong woman, Bustle previewing the 12th sesson wrote, "Meredith Grey has always been capable of being on her own. Grey's Anatomy is about Meredith's journey. Men and romantic interests are a part of her life, but they are not the priority. She doesn't need McDreamy. Grey's Anatomy doesn't need McDreamy. So even if the writers do decide to create a new love interest for Ms. Grey (Martin Henderson, perhaps?), it wouldn't matter. I have faith that the show's writers will do this storyline justice, because TV needs more strong single women — and Meredith seems like the perfect candidate." The site added, "This past season was almost a trial run for a McDreamy-less Grey's Anatomy. When Derek left for Washington D.C. to pursue his research, Meredith stayed behind and focused on her own career. She didn't chase him. Her priority were her children and the Grey Sloan Memorial Hospital. Meredith showed that she would never put aside her own dreams and aspirations for a man, and I believe that this won't change after Derek's death."
Pompeo has won and has been nominated for multiple awards for her portrayal of Grey. She and the Grey's Anatomy cast won Best Ensemble in a Television Series at the 2006 Satellite Awards. During the following year's ceremony, she was named Best Actress in a Television Drama Series. She was among the Grey's Anatomy cast members awarded the Outstanding Performance by an Ensemble in a Drama Series accolade at the 13th Screen Actors Guild Awards, and received nominations in the same category in 2006 and 2008. Pompeo received a Best Performance by an Actress in a Drama Series nomination at the 64th Golden Globe Awards – the program won Best Drama Series at the same ceremony. Also in 2007, Pompeo and the female cast and crew of Grey's Anatomy received the Women in Film Lucy Award, which honors those "whose work in television has positively influenced attitudes toward women."
Pompeo's performance has garnered her multiple People's Choice Awards. At the 37th People's Choice Awards, she was nominated against Dempsey and Oh in the Favorite TV Doctor category, and the following year, she was a contender in the Favorite TV Drama Actress category. Since 2012 Pompeo has received nomination at the People's Choice Awards every year in two categories at 40th People's Choice Awards alongside Patrick Dempsey and Sandra Oh respectively. She won the Best Drama Actress Award at both the 39th People's Choice Awards and the 41st People's Choice Awards. In 2007, show-business awards reporter Tom O'Neil commented that Pompeo was overdue an Emmy Award nomination for her role in Grey's Anatomy. Readers of O'Neil's awards website, The Envelope, included Pompeo in their 2009 nominations for Best Drama Actress in the site's Gold Derby TV Awards. Entertainment Weekly launched the EWwy Awards in 2008, to honor actors who have not received Emmy nominations. Pompeo was nominated in the Best Actress in a Drama Series category, and placed fourth, with 19 percent of readers' votes.
- "Yesterday". Grey's Anatomy. Season 2. Episode 18. February 19, 2006. ABC.
- "Ellen Pompeo Biography". Yahoo. Yahoo! Movies. Retrieved May 10, 2012.
- Ryan, Maureen (September 30, 2005). "Chicago as a 'Grey' area?". Los Angeles Times. Retrieved January 23, 2012.
- Fonseca, Nicholas (September 16, 2005). "Playing Doctors". Entertainment Weekly. Time Inc. Retrieved January 23, 2012.
- "Interview: Ellen Pompeo from Grey's Anatomy". Fanbolt. Retrieved May 10, 2012.
|last1=in Authors list (help)
- Winfrey, Oprah (December 2006). "Oprah Talks to Shonda Rhimes". O, The Oprah Magazine. Harpo Productions, Inc. Retrieved May 24, 2012.
- McNamara, Mary (May 15, 2005). "'Grey's' takes a scalpel to standard procedure". Los Angeles Times. Retrieved January 23, 2012.
- Brownfield, Paul (March 25, 2005). "Lessons in the OR and via voice-over". Los Angeles Times. Retrieved January 23, 2012.
- Stanley, Alessandra (March 25, 2005). "Tales of Sex and Surgery". New York Times. Retrieved January 23, 2012.
- Andreeva, Nellie (March 9, 2007). ""Grey's Anatomy" stars get pay rises". Reuters. Retrieved June 19, 2012.
- "2012 Highest Paid TV Actresses". Forbes. Forbes, Inc. Retrieved August 25, 2012.
- "ABC Not Worried About 'Grey's Anatomy' Star Contracts; 'Revenge' Could Move Out Of Hamptons". Access Hollywood. Retrieved May 10, 2012.
- Bricker, Tierney. "Grey's Anatomy: Patrick Dempsey, Ellen Pompeo, Sandra Oh and Justin Chambers Set to Return!". NBC Universal. E! Online. Retrieved May 10, 2012.
- Ryan, Maureen (May 10, 2012). "'Once,' 'Revenge,' 'Grey's' And Two Comedies Renewed By ABC". Huffington Post. Huffington Post TV. Retrieved May 10, 2012.
- Rice, Lynette (1 June 2016). "Ellen Pompeo signs new deal with Grey's Anatomy". Entertainment Weekly. Retrieved 5 June 2016.
- Nilles, Billy (1 June 2016). "Ellen Pompeo Signs New Deal for Grey's Anatomy Season 13 Because No Duh". E!. Retrieved 5 June 2016.
- Grey's Anatomy Season Three DVD: Commentary Feature. Buena Vista, ABC. 2007.
- "Meredith Grey (Ellen Pompeo) Bio". American Broadcasting Company. Retrieved June 13, 2013.
- Keck, William (September 24, 2007). "A lighter shade of 'Grey's' on the set". USA Today. Retrieved May 10, 2012.
- "Ellen Pompeo Biography". People. Retrieved May 10, 2012.
- Rhimes, Shonda (May 17, 2006). "From Shonda Rhimes (FINALLY)…". Grey Matter. American Broadcasting Company. Retrieved July 14, 2012.
- Mitovich, Matt Webb. "Shonda Rhimes: Grey's Anatomy Finale Sets Up What May Be Original Cast's Final Run". TVLine. Retrieved May 10, 2012.
- McKee, Stacy (February 26, 2006). "From Stacy McKee, writer of "What Have I Done To Deserve This?"". ABC. Grey Matter. Retrieved June 19, 2012.
- McKee, Stacy (November 1, 2007). "Stacy McKee on "Kung Fu Fighting"...". ABC. Grey Matter. Retrieved June 19, 2012.
- Rhimes, Shonda (November 22, 2005). "From Shonda Rhimes, creator and writer of "Thanks For The Memories"". ABC. Grey Matter. Retrieved June 19, 2012.
- Mosthof, Marielle. "Ellen Pompeo Discusses Keeping the Spark Alive With Her On-Screen Hubby". Wet Paint. Retrieved May 10, 2012.
- Mitovich, Matt Webb. "Grey's Exclusive: Ellen Pompeo Weighs In on Mer-Der Fight: 'He Needs To Get Over It, Quick'". TVLine. Retrieved May 10, 2012.
- Rhimes, Shonda (October 3, 2007). "Shonda on the Season Premiere Episode "A Change Is Gonna Come"...". ABC. Grey Matter. Retrieved June 19, 2012.
- Rhimes, Shonda (February 12, 2006). "From Shonda: It's the end of the episode (as we know it)". ABC. Grey Matter. Retrieved June 19, 2012.
- Rhimes, Shonda (May 8, 2009). "Shonda Rhimes on "What a Difference a Day Makes"...". Grey Matter. American Broadcasting Company. Retrieved September 3, 2013.
- Gay, Verne (April 24, 2015). "Patrick Dempsey leaves 'Grey's Anatomy'; creator Shonda Rhimes says show entering 'uncharted territory'". Newsday. Retrieved May 1, 2015.
- Stanley, Alessandra (September 12, 2006). "TV Review: Men In Trees". The New York Times. The New York Times Company. Retrieved May 10, 2012.
- McNamara, Mary (July 17, 2009). "Seven Emmy nods a good fit". Los Angeles Times. Retrieved January 22, 2012.
- Hawkins, Alex (September 28, 2015). "Grey's Anatomy returns swinging in a new direction". Western Gazette. Retrieved October 1, 2015.
- Sepinwall, Alan (May 19, 2006). "Odds and sods". Sepinwall.blogspot.com. Retrieved August 12, 2012.
- "Grey's Anatomy: Season 3 Review". TV.IGN.com. Retrieved September 3, 2011.
- Rorke, Robert. "HEART THROB - GREY'S ANATOMY'S KATHERINE HEIGL ON SEX, LOVE AND CUPCAKES". New York Post. Retrieved May 19, 2012.
- Treble, Patricia (April 25, 2008). "Grey's Anatomy is on life support". Macleans.ca. Retrieved July 7, 2012.
- Potts, Kimberly (February 11, 2008). "Best TV Couples of All Time". AOL TV. Aol, Inc. Retrieved September 14, 2012.
- "Couples Pictures, Grey's Anatomy Photos - Photo Gallery: The Best TV Couples of All Time". TV Guide. Retrieved June 20, 2012.
- Morrison, Courtney (November 18, 2011). "Grey's Anatomy Midseason Report Card: B+". TV Fanatic. Retrieved September 1, 2013.
- http://www.slate.com/blogs/browbeat/2014/05/14/grey_s_anatomy_season_finale_ends_meredith_and_cristina_s_friendship_the.html. Missing or empty
- "Winner Announcement" (PDF). www.pressacademy.com. International Press Academy. Archived from the original (PDF) on July 10, 2007. Retrieved January 22, 2012.
- "Satellites Award 'No Country,' ' Juno'". Entertainment Weekly. Time Inc. December 17, 2007. Retrieved January 13, 2012.
- "The 13th Annual Screen Actors Guild Awards". www.sagawards.org. Screen Actors Guild. Retrieved January 13, 2012.
- "The 12th Annual Screen Actors Guild Awards". www.sagawards.org. Screen Actors Guild. Retrieved January 14, 2012.
- "The 14th Annual Screen Actors Guild Awards". www.sagawards.org. Screen Actors Guild Awards. Retrieved January 14, 2012.
- "Grey's Anatomy". www.goldenglobes.org. Hollywood Foreign Press Association. Retrieved January 22, 2012.
- Davidson, Ben G. (June 14, 2007). "WIF's Lucy Award goes to women of 'Grey's Anatomy'". The Hollywood Reporter. Nielsen Company. Retrieved January 22, 2012.(subscription required)
- "People's Choice Awards 2011 Nominees". www.peopleschoice.com. People's Choice Awards. Retrieved January 22, 2012.
- "People's Choice Awards 2012 Nominees". www.peopleschoice.com. People's Choice Awards. Retrieved January 22, 2012.
- O'Neil, Tom (June 6, 2007). "Battle to the finish". The Envelope (Los Angeles Times). Tribune Broadcasting. Retrieved January 22, 2012.
- O'Neil, Tom (June 30, 2009). "'30 Rock,' 'Mad Men' lead Gold Derby TV Award nominations". Gold Derby (Los Angeles Times). Tribune Broadcasting. Retrieved January 22, 2012.
- "EWwy Winners Revealed!". Entertainment Weekly. Time Inc. September 22, 2008. Retrieved January 22, 2012.
- "Grey's Anatomy: Episode Recap Guide". ABC. Retrieved June 19, 2012.