Mesterolone

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Mesterolone
Mesterolone.svg
Systematic (IUPAC) name
1α-Methyl-17β-hydroxy-5α-androstan-3-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Legal status
Pharmacokinetic data
Metabolism Liver
Identifiers
CAS Number 1424-00-6 N
ATC code G03BB01 (WHO)
PubChem CID 15020
ChemSpider 14296 YesY
UNII 0SRQ75X9I9 YesY
KEGG D04947 YesY
ChEMBL CHEMBL258918 YesY
Chemical data
Formula C20H32O2
Molar mass 304.467 g/mol
 NYesY (what is this?)  (verify)

Mesterolone is an orally applicable androgen and dihydrotestosterone (DHT) derivative. It is sold under the brand names Proviron (as Provironum in Asia-Pacific region) and Mestoranum, by Bayer Schering Pharma (earlier by Schering). In the late 1970s and early 1980s, it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[1]

Trials[edit]

In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.[2] In patients with dysthymia, unipolar, and bipolar depression significant improvement was observed.[2] In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[3]

Bodybuilding[edit]

Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered by bodybuilders to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.[4]

See also[edit]

  • Rosterolone (17-propylmesterolone) (17 beta-hydroxy-1 alpha-methyl-17 alpha-propyl-5 alpha-androstan-3-one). antiandrogen[5]

References[edit]

  1. ^ Nieschlag E, Behre HM, Bouchard P, et al. (2004). "Testosterone replacement therapy: current trends and future directions". Hum. Reprod. Update. 10 (5): 409–19. doi:10.1093/humupd/dmh035. PMID 15297434. 
  2. ^ a b Itil TM, Michael ST, Shapiro DM, Itil KZ (June 1984). "The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study)". Methods Find Exp Clin Pharmacol. 6 (6): 331–7. PMID 6431212. 
  3. ^ Kövary PM, Lenau H, Niermann H, Zierden E, Wagner H (May 1977). "Testosterone levels and gonadotrophins in Klinefelter's patients treated with injections of mesterolone cipionate". Arch Dermatol Res. 258 (3): 289–94. doi:10.1007/bf00561132. PMID 883846. 
  4. ^ Meso-RX Steroid Profiles - Proviron (Mesterolone)
  5. ^ Brooks, J. R.; Primka, R. L.; Berman, C; Krupa, D. A.; Reynolds, G. F.; Rasmusson, G. H. (1991). "Topical anti-androgenicity of a new 4-azasteroid in the hamster". Steroids. 56 (8): 428–33. doi:10.1016/0039-128x(91)90031-p. PMID 1788861. 

Further reading[edit]