Mestisko is a village and municipality in Svidník District in the Prešov Region of north-eastern Slovakia.
In historical records the village was first mentioned in 1414.
The municipality lies at an altitude of 254 metres and covers an area of 11.057km². It has a population of about 464 people.
Coordinates: 49°15′N 21°35′E / 49.250°N 21.583°E / 49.250; 21.583