Metacycline

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Metacycline
Metacycline.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.011.834 Edit this at Wikidata
Chemical and physical data
FormulaC22H22N2O8
Molar mass442.419 g/mol g·mol−1
3D model (JSmol)
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Metacycline is a tetracycline antibiotic. It is used as a precursor in the industrial synthesis of doxycycline hyclate.

It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro.[1]

References[edit]

  1. ^ Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M (2011). "Identification of clinically used drugs that activate pregnane X receptors" (PDF). Drug Metab. Dispos. 39 (1): 151–9. doi:10.1124/dmd.110.035105. PMC 3014269. PMID 20966043.