Methanogen homoaconitase
| Methanogen homoaconitase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.114 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction
- (R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)
- (1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
- (1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
References
- ^ Drevland, R.M.; Jia, Y.; Palmer, D.R.; Graham, D.E. (2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". J. Biol. Chem. 283: 28888–28896. doi:10.1074/jbc.m802159200. PMID 18765671.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- Methanogen+homoaconitase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)