Metharbital Clinical data Synonyms Endiemal, metharbitone, methobarbitone  Routes of administration By mouth ( tablets) ATC code Legal status Legal status
5,5-Diethyl-1-methylpyrimidine-2,4,6(1 H,3 H,5 H)-trione CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEMBL ECHA InfoCard 100.000.011 Chemical and physical data Formula C 9 H 14 N 2 O 3 Molar mass 198.219 g/mol 3D model ( JSmol)
Metharbital was patented in 1905 by Emil Fischer working for Merck. It was marketed as  Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.  It has similar properties to  phenobarbital.
History [ edit ]
1952 Gemonil was introduced by Abbott Laboratories. 1990 Abbott stopped marketing.
Synthesis [ edit ]
Metharbital can be synthesized from 2,2-diethylmalonic acid and
O-methylisourea.  
References [ edit ]
The Comparative Toxicogenomics Database: Metharbital
^ US Patent 782742
The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5
^ A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949)
Snyder, J. A.; Link, K. P. (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society. 75 (8): 1881. doi: 10.1021/ja01104a030.
U.S. Patent 782,742