Methenyltetrahydrofolate cyclohydrolase

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methenyltetrahydrofolate cyclohydrolase
1dib.jpg
Methenyltetrahydrofolate cyclohydrolase dimer, Human
Identifiers
EC number3.5.4.9
CAS number9027-97-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) is an enzyme that catalyzes the chemical reaction

5,10-methenyltetrahydrofolate + H2O 10-formyltetrahydrofolate

Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H2O, whereas its product is 10-formyltetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.

This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

Synonyms[edit]

The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing).

Other names in common use include:

  • Citrovorum factor cyclodehydrase
  • cyclohydrolase
  • formyl-methenyl-methylenetetrahydrofolate synthetase (combined).

Structural studies[edit]

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1A4I, 1DIA, 1DIB, 1DIG, 2C2X, and 2C2Y.

References[edit]

  • Rabinowitz JC, Pricer WE (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation". J. Am. Chem. Soc. 78 (16): 4176&ndash, 4178. doi:10.1021/ja01597a094.
  • Tabor H, Wyngarden L (July 1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid". The Journal of Biological Chemistry. 234 (7): 1830–46. PMID 13672973.