Methenyltetrahydromethanopterin cyclohydrolase

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methenyltetrahydromethanopterin cyclohydrolase
4gvq.jpg
Methenyltetrahydromethanopterin cyclohydrolase trimer, Archaeoglobus fulgidus
Identifiers
EC number3.5.4.27
CAS number99533-50-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a methenyltetrahydromethanopterin cyclohydrolase (EC 3.5.4.27) is an enzyme that catalyzes the chemical reaction

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O 5-formyl-5,6,7,8-tetrahydromethanopterin

Thus, the two substrates of this enzyme are 5,10-methenyl-5,6,7,8-tetrahydromethanopterin and H2O, whereas its product is 5-formyl-5,6,7,8-tetrahydromethanopterin.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing). Other names in common use include 5,10-methenyltetrahydromethanopterin cyclohydrolase, N5,N10-methenyltetrahydromethanopterin cyclohydrolase, and methenyl-H4MPT cyclohydrolase. This enzyme participates in folate biosynthesis.

References[edit]

  • Donnelly MI, Escalante-Semerena JC, Rinehart KL, Wolfe RS (1985). "Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium". Arch. Biochem. Biophys. 242 (2): 430&ndash, 9. doi:10.1016/0003-9861(85)90227-9. PMID 4062290.