Methionine-S-oxide reductase

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Methionine-S-oxide reductase
Identifiers
EC number1.8.4.5
CAS number70248-65-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Methionine-S-oxide reductase (EC 1.8.4.5, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase) is an enzyme with systematic name L-methionine:thioredoxin-disulfide S-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

L-methionine + thioredoxin disulfide + H2O L-methionine S-oxide + thioredoxin

In the reverse reaction, dithiothreitol can replace reduced thioredoxin.

References[edit]

  1. ^ Black, S.; Harte, E.M.; Hudson, B.; Wartofsky, L. (1960). "A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides". J. Biol. Chem. 235: 2910–2916.
  2. ^ Ejiri SI, Weissbach H, Brot N (July 1979). "Reduction of methionine sulfoxide to methionine by Escherichia coli". Journal of Bacteriology. 139 (1): 161–4. PMC 216841. PMID 37234.
  3. ^ Ejiri SI, Weissbach H, Brot N (March 1980). "The purification of methionine sulfoxide reductase from Escherichia coli". Analytical Biochemistry. 102 (2): 393–8. doi:10.1016/0003-2697(80)90173-6. PMID 6999943.

External links[edit]