Chloromethylisothiazolinone; Chloromethylisothiazolone; Methylchloroisothiazolinone; Methylchloroisothiazolone; CMI; CMIT; MCI; MCIT
|Jmol 3D model||Interactive image|
|Molar mass||149.59 g·mol−1|
|R-phrases||R23/24/25 R34 R43 R50/53|
|S-phrases||(S2) S26 S28 S36/37/39 S45 S60 S61|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Methylchloroisothiazolinone (5-chloro-2-methyl-4-isothiazolin-3-one), also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi.
Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.
In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, accepted concentrations are 15 ppm in rinse-offs and 8 ppm in other cosmetics. In Canada, the accepted concentrations are 15 ppm and 7.5 ppm respectively. The Canadian levels are also reflected in a paper published in the International Journal of Toxicology.
The International Agency for Research on Cancer (IARC), does not currently list methylchloroisothiazolinone as a known, probable, or possible human carcinogen, nor have in vivo tests found evidence of carcinogenic activity.
Allergic contact dermatitis
||This section needs more medical references for verification or relies too heavily on primary sources. (August 2013)|
Methylchloroisothiazolinone is an allergen and can cause severe skin reactions in some people. Since 2013 the use of the product particularly in cosmetics has received increased media coverage in the UK. In 2013 GP doctors asked cosmetics companies to remove it from products. Some cosmetics with the MI in have been investigated by the BBC Watchdog programme. The first publication of the preservative as a contact allergen was in 1988. A common indication of an allergic reaction is eczema-like symptoms including redness and itching, and upon longer exposure also burning sensations and blisters on the part of the skin that is exposed to the allergen.[medical citation needed] Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported. Continued exposure can lead to high sensitization which will be triggered each time the individual comes in contact with the allergen due to the memory T-cells that will remain in the local skin area.[medical citation needed]
- Reinhard; et al. (2001). "Preservation of products with MCI/MI in Switzerland". Contact Dermatitis. 45 (5): 257–264. doi:10.1034/j.1600-0536.2001.450501.x. PMID 11722483.
- Knudsen BB, Menne T (1990). "Kathon CG--a new contact sensitizing preservative". Ugeskrift for Lægerer. 152 (10): 656–657. PMID 2321281.
- "Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients". Health Canada. Retrieved 24 February 2015.
- "6 Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone". sagepub.com. International Journal of Toxicology. January 1992. pp. 75–128. doi:10.3109/10915819209141993. Retrieved 24 February 2015.
- "International Agency for Research on Cancer". IARC (updated November 2007). Retrieved 7 January 2008.
- Pirmez R, Fernandes ALC, Melo MGM. Photoaggravated contact dermatitis to Kathon CG (methylchloroisothiazolinone/methylisothiazolinone): a novel pattern of involvement in a growing epidemic? Br J Dermatol. 2015 Jun 30. doi: 10.1111/bjd.13986. [Epub ahead of print] http://onlinelibrary.wiley.com/doi/10.1111/
- De Groot, A. C.; Weyland, J. W. (1988). "Kathon CG: A review". Journal of the American Academy of Dermatology. 18 (2 Pt 1): 350–358. doi:10.1016/s0190-9622(88)70051-1. PMID 3279090.
Pirmez R, Fernandes ALC, Melo MGM. Photoaggravated contact dermatitis to Kathon CG (methylchloroisothiazolinone/methylisothiazolinone): a novel pattern of involvement in a growing epidemic? Br J Dermatol. 2015 Jun 30. doi: 10.1111/bjd.13986. [Epub ahead of print] http://onlinelibrary.wiley.com/doi/10.1111/bjd.13986/abstract