3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||149.59 g·mol−1|
|R-phrases (outdated)||R23/24/25 R34 R43 R50/53|
|S-phrases (outdated)||(S2) S26 S28 S36/37/39 S45 S60 S61|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi.
Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone.
Methylchloroisothiazolinone can cause allergic reactions in some people. The first publication of the preservative as a contact allergen was in 1988. Cases of photoaggravated allergic contact dermatitis, i.e. worsening of skin lesions after sun exposure, have also been reported.
In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, accepted concentrations are 15 ppm in rinse-offs and 8 ppm in other cosmetics. In Canada, the accepted concentrations are 15 ppm and 7.5 ppm respectively. The Canadian levels are also reflected in a paper published in the International Journal of Toxicology.
As of 2008, the International Agency for Research on Cancer (IARC), did not list methylchloroisothiazolinone as a known, probable, or possible human carcinogen, nor have in vivo tests found evidence of carcinogenic activity.
- Reinhard; et al. (2001). "Preservation of products with MCI/MI in Switzerland". Contact Dermatitis. 45 (5): 257–264. doi:10.1034/j.1600-0536.2001.450501.x. PMID 11722483.
- Knudsen BB, Menne T (1990). "Kathon CG--a new contact sensitizing preservative". Ugeskrift for Lægerer. 152 (10): 656–657. PMID 2321281.
- Pirmez, R.; Fernandes, A.L.C.; Melo, M.G.M. (2015). "Photoaggravated contact dermatitis to Kathon CG (methylchloroisothiazolinone/Methylisothiazolinone): A novel pattern of involvement in a growing epidemic?". British Journal of Dermatology. 173 (5): 1343–1344. doi:10.1111/bjd.13986. PMID 26130214.
- De Groot, A. C.; Weyland, J. W. (1988). "Kathon CG: A review". Journal of the American Academy of Dermatology. 18 (2 Pt 1): 350–358. doi:10.1016/s0190-9622(88)70051-1. PMID 3279090.
- "Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients". Health Canada. 18 June 2004. Retrieved 24 February 2015.
- "6 Final Report on the Safety Assessment of Methylisothiazolinone and Methylchloroisothiazolinone". Journal of the American College of Toxicology. 11: 75–128. January 1992. doi:10.3109/10915819209141993. Retrieved 24 February 2015.
- "International Agency for Research on Cancer". IARC (updated November 2007). Retrieved 7 January 2008.