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Clinical data
Synonyms Dihydroheterocodeine
ATC code
  • none
Legal status
Legal status
CAS Number
PubChem CID
Chemical and physical data
Formula C18H23NO3
Molar mass 301.38 g/mol
3D model (JSmol)
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Methyldihydromorphine (dihydroheterocodeine)[1] is a semi-synthetic opioid originally developed in Germany in 1936, controlled under both domestic law and UN conventions because of its possible potential for abuse. Methyldihydromorphine is related to heterocodeine and is not a synonym for dihydrocodeine. Its structure suggests that it is six to nine times stronger than morphine and 72 times stronger than dihydrocodeine.

This compound is a derivative of hydromorphone[2] It has been found to be 33 per cent the analgesic potency of morphine with a substantially longer duration of action. [3] So far, little is currently known about this compound. It is a Schedule I controlled substance in the United States with an ACSCN of 9304 and a 2013 annual manufacturing quota of 2 grammes.[4]


  1. ^ U.S. Patent 2,104,058
  2. ^ Morphine & Allied Drugs, Randall and Reynolds, Toronto 1957, pp 194
  3. ^ Morphine & Allied Drugs, Randall and Reynolds, Toronto 1957, pp 194
  4. ^ Quotas - 2013