Methylpiperidinopyrazole

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Methylpiperidinopyrazole
Methylpiperidinopyrazole.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C29H31N3O3
Molar mass 469.57474 g/mol
3D model (JSmol)

Methylpiperidinopyrazole (MPP) is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor.[1][2][3] It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.[4]

See also[edit]

References[edit]

  1. ^ Tony M. Plant; Anthony J. Zeleznik (15 November 2014). Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. pp. 2311–. ISBN 978-0-12-397769-4. 
  2. ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9. 
  3. ^ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS). ProQuest. 2008. pp. 11–. ISBN 978-0-549-90990-3. 
  4. ^ Eckhard Ottow; Hilmar Weinmann (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 50–. ISBN 978-3-527-62330-3.