Metirosine

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Metirosine
Metirosine.svg
Systematic (IUPAC) name
(2S)-2-amino- 3-(4-hydroxyphenyl)- 2-methylpropanoic acid
Clinical data
Trade names Demser
AHFS/Drugs.com Consumer Drug Information
Pharmacokinetic data
Biological half-life 3.4–3.7 hours
Identifiers
CAS Number 672-87-7 YesY
ATC code C02KB01 (WHO)
PubChem CID 10123
IUPHAR/BPS 6956
DrugBank DB00765 YesY
ChemSpider 390103 YesY
UNII DOQ0J0TPF7 YesY
KEGG D00762 YesY
ChEMBL CHEMBL1200862 N
Chemical data
Formula C10H13NO3
Molar mass 195.215 g/mol
 NYesY (what is this?)  (verify)

Metirosine (INN and BAN; α-Methyltyrosine, Metyrosine USAN, AMPT) is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.

Clinical use[edit]

Metirosine has been used in the treatment of pheochromocytoma.[1] It is contra-indicated for the treatment of essential hypertension.

However it is now rarely used in medicine, its primary use being in scientific research to investigate the effects of catecholamine depletion on behaviour.[2]

See also[edit]

References[edit]

  1. ^ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (August 1982). "Alpha-methyltyrosine in the management of phaeochromocytoma". Thorax 37 (8): 632–3. doi:10.1136/thx.37.8.632. PMC 459390. PMID 7179194. 
  2. ^ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507