The station logo depicts the tallest building in the nearby Nonoalco-Tlatelolco residential estate, the triangular Torre Insignia, which was formerly a Banobras building. The 127 metres (417 ft) tower houses a 47-bell carillon – a gift to the Mexican people from the citizens of Belgium. Metro Tlatelolco is directly connected with the main square of the vast, 1960s residential estate.
The station opened on 20 November 1970 with service southward towards Hospital General. Northward service towards Indios Verdes started nearly 8 years later on 25 August 1978.