Mga (protein)

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Symbol Mga
Pfam PF05043
Pfam clan CL0123
InterPro IPR007737

Mga is a DNA-binding protein that activates the expression of several important virulence genes in Streptococcus pyogenes (group A Streptococcus, GAS) in response to changing environmental conditions.[1] The family also contains VirR like proteins which match only at the C-terminus.

Mga is a wide-reaching regulator, affecting gene expression in over 10% of the S. pyrogenes genome.[2] The other large regulator of virulence in GAS is the CovR/S two-component system, which affects the expression of approximately 15% of the genome.[3] The two systems are linked through another protein, RivR, and a small non-coding RNA RivX.[4]


  1. ^ McIver KS, Myles RL (March 2002). "Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus". Molecular Microbiology. 43 (6): 1591–601. doi:10.1046/j.1365-2958.2002.02849.x. PMID 11952907.
  2. ^ Hondorp ER, McIver KS (December 2007). "The Mga virulence regulon: infection where the grass is greener". Molecular Microbiology. 66 (5): 1056–65. doi:10.1111/j.1365-2958.2007.06006.x. PMID 18001346.
  3. ^ Churchward G (April 2007). "The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci". Molecular Microbiology. 64 (1): 34–41. doi:10.1111/j.1365-2958.2007.05649.x. PMID 17376070.
  4. ^ Roberts SA, Scott JR (December 2007). "RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon". Molecular Microbiology. 66 (6): 1506–22. doi:10.1111/j.1365-2958.2007.06015.x. PMID 18005100.
This article incorporates text from the public domain Pfam and InterPro: IPR007737