miR-191

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miR-191
Mir-191 SS.png
Conserved secondary structure of miR-191 microRNA precursor
Identifiers
Symbol miR-191
Alt. Symbols MIR191
Rfam RF00764
miRBase MI0000465
miRBase family MIPF0000194
Entrez 406966
HUGO 31561
RefSeq NR_029690
Other data
RNA type miRNA
Domain(s) Mammalia
GO 0035195
SO 0001244
Locus Chr. 3 p21.31

miR-191 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]

miR-191 has been found to be dysregulated in a large number of different types of human tumour, including those of colorectal,[3] breast and prostate cancers.[4] Despite these cancer links, target genes of the mature miRNA have not been characterised, and it is not known which factors lead to its dysregulation in certain tumour cells.[5]

The expression profile of miR-191 could be implemented in prognosis of acute myeloid leukaemia, with higher than average levels of miR-191 suggesting a lower survival probability.[6]

References[edit]

  1. ^ Ambros V (Dec 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. PMID 11779458. doi:10.1016/S0092-8674(01)00616-X. 
  2. ^ Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R (Nov 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631–40. PMID 16271387. doi:10.1016/j.cell.2005.10.022. 
  3. ^ Xi Y, Formentini A, Chien M, Weir DB, Russo JJ, Ju J, Kornmann M, Ju J (2006). "Prognostic Values of microRNAs in Colorectal Cancer". Biomarker Insights. 2: 113–121. PMC 2134920Freely accessible. PMID 18079988. 
  4. ^ Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM (Feb 2006). "A microRNA expression signature of human solid tumors defines cancer gene targets". Proceedings of the National Academy of Sciences of the United States of America. 103 (7): 2257–61. PMC 1413718Freely accessible. PMID 16461460. doi:10.1073/pnas.0510565103. 
  5. ^ Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H (2010-02-18). "Novel genetic variants in miR-191 gene and familial ovarian cancer". BMC Cancer. 10: 47. PMC 2831822Freely accessible. PMID 20167074. doi:10.1186/1471-2407-10-47. 
  6. ^ Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM (Mar 2008). "MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia". Blood. 111 (6): 3183–9. PMC 2265455Freely accessible. PMID 18187662. doi:10.1182/blood-2007-07-098749. 

External links[edit]