miR-208

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miR-208
Mir-208 SS.png
Conserved secondary structure of miR-208 microRNA precursor
Identifiers
Symbol miR-208
Alt. Symbols MIR208
Rfam RF00749
miRBase MI0000251
miRBase family MIPF0000178
Entrez 406990
HUGO 31585
OMIM 611116
RefSeq NR_029595
Other data
RNA type miRNA
Domain(s) Metazoa
GO 0035195
SO 0001244
Locus Chr. 14 q11.2

miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]

In humans, the gene for miR-208 is located in an intron of MYH7.[3]

Function[edit]

miR-208 has been deemed a "myomiR"[3] as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133.[3] miR-208 is thought to be dysregulated in various cardiovascular diseases.[4][5]

miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.[3] It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.[6]

Applications[edit]

A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy.[7] Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.[8]

References[edit]

  1. ^ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential.". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
  2. ^ Gregory, RI; Chendrimada, TP; Cooch, N; Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.". Cell. 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387. 
  3. ^ a b c d Malizia, AP; Wang, DZ (Mar–Apr 2011). "MicroRNAs in cardiomyocyte development.". Wiley interdisciplinary reviews. Systems biology and medicine. 3 (2): 183–90. doi:10.1002/wsbm.111. PMC 3058499Freely accessible. PMID 21305703. 
  4. ^ Cai, B; Pan, Z; Lu, Y (2010). "The roles of microRNAs in heart diseases: a novel important regulator.". Current medicinal chemistry. 17 (5): 407–11. doi:10.2174/092986710790226129. PMID 20015039. (subscription required)
  5. ^ Han, M; Toli, J; Abdellatif, M (May 2011). "MicroRNAs in the cardiovascular system.". Current Opinion in Cardiology. 26 (3): 181–9. doi:10.1097/HCO.0b013e328345983d. PMID 21464712. 
  6. ^ van Rooij, E; Sutherland, LB; Qi, X; Richardson, JA; Hill, J; Olson, EN (2007-04-27). "Control of stress-dependent cardiac growth and gene expression by a microRNA.". Science. 316 (5824): 575–9. doi:10.1126/science.1139089. PMID 17379774. 
  7. ^ Satoh, M; Minami, Y; Takahashi, Y; Tabuchi, T; Nakamura, M (May 2010). "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy.". Journal of cardiac failure. 16 (5): 404–10. doi:10.1016/j.cardfail.2010.01.002. PMID 20447577. 
  8. ^ Ji, X; Takahashi, R; Hiura, Y; Hirokawa, G; Fukushima, Y; Iwai, N (Nov 2009). "Plasma miR-208 as a biomarker of myocardial injury.". Clinical Chemistry. 55 (11): 1944–9. doi:10.1373/clinchem.2009.125310. PMID 19696117. 

Further reading[edit]