miR-296

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miR-296
Mir-296 SS.png
Conserved secondary structure of miR-296 microRNA precursor
Identifiers
Symbol miR-296
Alt. Symbols MIR296
Rfam RF00733
miRBase MI0000747
miRBase family MIPF0000159
Entrez 407022
HUGO 31617
OMIM 610945
RefSeq NR_029844
Other data
RNA type miRNA
Domain(s) Mammalia
GO 0035195
SO 0001244
Locus Chr. 20 q13.32
PDB structures PDBe

miR-296 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]

miR-296 has been named an "angiomiR"[3] due to being characterised as a microRNA which regulates angiogenesis, the process of growth and creation of new blood vessels.[4] miR-296 is thought to have a specific role in cancer in promoting tumour angiogenesis.[3][5] It achieves this by targeting HGS mRNA, reducing its expression in endothelial cells which then results in greater number of VEGF receptors.[3][6]

miR-296 has predicted target sites in the transcription factor NANOG[7] and may also contribute to carcinogenesis by dysregulating p53.[8]

References[edit]

  1. ^ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
  2. ^ Gregory, RI; Chendrimada, TP; Cooch, N; Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387. 
  3. ^ a b c Wang, S; Olson, EN (June 2009). "AngiomiRs--key regulators of angiogenesis". Current Opinion in Genetics & Development. 19 (3): 205–11. doi:10.1016/j.gde.2009.04.002. PMC 2696563Freely accessible. PMID 19446450. 
  4. ^ Anand, S; Cheresh, DA (May 2011). "MicroRNA-mediated regulation of the angiogenic switch". Current Opinion in Hematology. 18 (3): 171–6. doi:10.1097/MOH.0b013e328345a180. PMC 3159578Freely accessible. PMID 21423013.  (subscription required)
  5. ^ Bonauer, A; Boon, RA; Dimmeler, S (August 2010). "Vascular microRNAs". Current drug targets. 11 (8): 943–9. doi:10.2174/138945010791591313. PMID 20415654. 
  6. ^ Würdinger, T; Tannous, BA; Saydam, O; Skog, J; Grau, S; Soutschek, J; Weissleder, R; Breakefield, XO; Krichevsky, AM (2008-11-04). "miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells". Cancer Cell. 14 (5): 382–93. doi:10.1016/j.ccr.2008.10.005. PMC 2597164Freely accessible. PMID 18977327. 
  7. ^ Tay, Y; Zhang, J; Thomson, AM; Lim, B; Rigoutsos, I (2008-10-23). "MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation". Nature. 455 (7216): 1124–8. doi:10.1038/nature07299. PMID 18806776. 
  8. ^ Yoon, AR; Gao, R; Kaul, Z; Choi, IK; Ryu, J; Noble, JR; Kato, Y; Saito, S; Hirano, T; Ishii, T; Reddel, RR; Yun, CO; Kaul, SC; Wadhwa, R (2011-06-30). "MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region". Nucleic Acids Research. 39 (18): 8078–91. doi:10.1093/nar/gkr492. PMC 3185413Freely accessible. PMID 21724611. 

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