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Description microRNA annotation and deep-sequencing data.
Research center University of Manchester
Laboratory Faculty of Life Sciences
Authors Ana Kozomara
Primary citation Kozomara & al. (2011)[1]
Release date 2010
Website http://www.mirbase.org/

In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations.[1][2][3][4] As of September 2010 it contained information about 15,172 microRNAs.[1] This number has rose to 38,589 by March 2018[5]. The miRBase registry provides a centralised system for assigning new names to microRNA genes.[6]

miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003.[7]

According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims:[1]

  1. To provide a consistent naming system for microRNAs
  2. To provide a central place collecting all known microRNA sequences
  3. To provide human and computer readable information for each microRNA
  4. To provide primary evidence for each microRNA
  5. To aggregate and link to microRNA target information

MiRBase contains miRNAs belonging of various species belonging to Alveolata, Chromalveolata, Metazoa, Mycetozoa, Viridiplantae and Viruses. For the Viridiplantae, in release 21 (2014) data is available for 73 species. This includes 4800 unique mature miRNAs and 8480 precursor sequences[8].

The current version of MiRBase is release 22 (March 2018).


  1. ^ a b c d Kozomara, A.; Griffiths-Jones, S. (2010). "MiRBase: integrating microRNA annotation and deep-sequencing data". Nucleic Acids Research. 39 (Database issue): D152–7. doi:10.1093/nar/gkq1027. PMC 3013655Freely accessible. PMID 21037258. 
  2. ^ Griffiths-Jones, Sam (2010). "MiRBase: microRNA Sequences and Annotation": Unit 12.9.1–10. doi:10.1002/0471250953.bi1209s29. 
  3. ^ Griffiths-Jones, S.; Saini, H. K.; Van Dongen, S.; Enright, A. J. (2007). "MiRBase: tools for microRNA genomics". Nucleic Acids Research. 36 (Database issue): D154–8. doi:10.1093/nar/gkm952. PMC 2238936Freely accessible. PMID 17991681. 
  4. ^ Griffiths-Jones, Sam (2006). "MiRBase: the MicroRNA Sequence Database". 342: 129–38. doi:10.1385/1-59745-123-1:129. 
  5. ^ "Mirbase 22 Release Notes". 
  6. ^ Griffiths-Jones, S.; Grocock, RJ; Van Dongen, S; Bateman, A; Enright, AJ (2006). "MiRBase: microRNA sequences, targets and gene nomenclature". Nucleic Acids Research. 34 (Database issue): D140–4. doi:10.1093/nar/gkj112. PMC 1347474Freely accessible. PMID 16381832. 
  7. ^ Griffiths-Jones S (January 2004). "The microRNA Registry". Nucleic Acids Res. 32 (Database issue): D109–11. doi:10.1093/nar/gkh023. PMC 308757Freely accessible. PMID 14681370. 
  8. ^ Nithin, Chandran; Thomas, Amal; Basak, Jolly; Bahadur, Ranjit Prasad (2017-11-15). "Genome-wide identification of miRNAs and lncRNAs in Cajanus cajan". BMC Genomics. 18: 878. doi:10.1186/s12864-017-4232-2. ISSN 1471-2164. 

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