Michael D. West
|Michael D. West, PhD|
|Born||Niles, Michigan, USA|
|Alma mater||Rensselaer Polytechnic Institute (B.S.)
Andrews University (M.S.)
Baylor College of Medicine (Ph.D.)
|Known for||Founder and CEO of AgeX Therapeutics, Co-CEO of BioTime, Founder of Geron Corporation, former CEO of Advanced Cell Technology, research in gerontology, stem cell science, cellular aging, and telomeres|
|Influences||James Thomson, Elizabeth Blackburn, Leonard Hayflick|
Michael D. West is a gerontologist, and a pioneer in stem cells, cellular aging and telomerase,. He is the founder and CEO of AgeX Therapeutics a startup focused on the field of interventional gerontology, and Co-CEO of its parent company, BioTime, Inc. (AMEX: BTX) of Alameda, California (San Francisco Bay Area), a biotechnology company regarded as a leader in the field of regenerative medicine with a focus on cell therapy.
Prior to joining BioTime, West was Chairman of the Board, Chief Scientific Officer and CEO of Advanced Cell Technology (ACT), another biotechnology company focused on stem cell research. ACT later changed its name to Ocata Therapeutics, and was acquired by Japanese pharmaceutical company Astellas Pharma for US$379M or $8.50 per share in February 2016.
Prior that, West was founder, director, and Chief Scientific officer of Geron, for which he secured venture capital investment from Kleiner Perkins Caufield & Byers, Venrock and Domain Associates. At Geron, West initiated and managed programs in telomere biology relating to aging, cancer and human embryonic stem cell technology.
West organized the first collaborative effort to isolate human pluripotent (embryonic) stem cells for the purpose of manufacturing products in regenerative medicine in collaboration with James Thomson at the University of Wisconsin at Madison John Gearhart at Johns Hopkins School of Medicine and Roger Pedersen at the University of California, San Francisco.
In their telomerase research, West and colleagues at Geron cloned the RNA component of telomerase and collaborated with Thomas Cech (winner of 1989 Nobel Prize in Chemistry), with whom they cloned the catalytic component of the telomerase enzyme, and sponsored collaborative research in the laboratory of Carol Greider, then at Cold Spring Harbor Laboratory. Geron published evidence of the role of telomerase in cancer and cell immortalization in collaboration with Woodring Wright and Jerry Shay at the University of Texas Southwestern Medical Center at Dallas.
For the company's Scientific and Clinical Advisory Board, he recruited Günter Blobel (winner of the 1999 Nobel Prize in Physiology), Leonard Hayflick, Carol Greider (winner of the 2009 Nobel Prize in Medicine), James Watson (winner of the 1962 Nobel Prize in medicine), and others.
West has authored and co-edited books on topics such as animal cloning, aging, gerontology, stem cells, stem cell biology, and regenerative medicine.
- 2002 Principles of Cloning ISBN 0-12-174597-X
- 2003 The Immortal Cell, by Michael D. West, Doubleday ISBN 978-0-385-50928-2
- 2004 Handbook of Stem Cells: Volume 1 Embryonic Stem Cells ISBN 0-12-436642-2
- 2004 Handbook of Stem Cells: Volume 2 Adult and Fetal Stem Cells ISBN 0-12-436644-9
- 2006 Essentials of Stem Cell Biology ISBN 0-12-088442-9
- 2010 The Future of Aging ISBN 9048139988
- 2010 The Future of Aging: Pathways to Human Life Extension ISBN 978-90-481-3998-9
- Stem cells
- embryonic stem cells
- pluripotent stem cells
- regenerative medicine
- tissue engineering
- somatic cell nuclear transfer
- Advanced Cell Technology
- Geron Corporation
- Kleiner Perkins Caufield & Byers
- "Who Is Doctor West, And Why Has He Got George Bush So Ticked Off?". Fortune Small Business. April 1, 2002.
- "Michael D. West Ph.D.: Executive Profile & Biography". Bloomberg. Bloomberg L.P. Retrieved 15 May 2015.
- "On Michael D. West and the Medical Crusade to Defeat Death". Trinity International University blog. May 9, 2011.
- "A Blood Test Offers Clues to Longevity". New York Times. May 18, 2011.
- "The Smart Money Is Piling Into Regenerative Medicine". Forbes.com. April 14, 2017.
- "AgeX Therapeutics lands $10 mln". PE HUB. August 17, 2017.
- "SEC Schedule 13G, filed Feb. 17, 1999".
- "Geron Corporation 10K 1996".
- "Bloomberg Longevity Economy Conference 2013 Panelist Bio". Archived from the original on 2013-08-03.
- Gearhart J (December 12, 2008). "A decade of stem-cell research. An interview with John Gearhart, Director of the Institute for Regenerative Medicine at the University of Pennsylvania, USA". EMBO Reports. 10: 12–6. PMC . PMID 19079128. doi:10.1038/embor.2008.235.
- "Stem-Cell Researcher Plans Move to U.K., Citing Unfriendly Political Climate in U.S.". The Wall Street Journal. July 16, 2001.
- Feng, J., Funk, W.D., Wang, S-S, Weinrich, S.L., Avilion, A.A., Chiu, C-P., Adams, R., Chang, E., Allsopp, R.C., Siyuan Le, J-Y., West, M.D., Harley, C.B., Andrews, W.H., Greider, C.W., Villeponteau, B.V. (1 September 1995). "The RNA Component of Human Telomerase". Science. 269: 1236–1241. PMID 7544491. doi:10.1126/science.7544491.
- "Biotechnology Company Says It Has Cloned a Cancer Gene". The New York Times. August 18, 1997.
- Hall, Stephen (2003). "Merchants of Immortality: Chasing the New Dream of Life Extension". Houghton Mifflin. ISBN 0547561571. Page 320.
- Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. (23 December 1994). "Specific association of human telomerase activity with immortal cells and cancer.". Science. 266: 2011–14. PMID 7605428. doi:10.1126/science.7605428.
- Hall, Stephen (2003). "Merchants of Immortality: Chasing the New Dream of Life Extension". Houghton Mifflin. ISBN 0547561571. Page 151.
- "Geron Corporation 10K 1996".
- "Google Patent Search: West, Michael D".
- "Michael David West CV" (PDF).
- Dr. West's webpage
- Michael West on Quora
- Dr. West's Biography
- BioTime, Inc.
- Bio of Dr. West on Bloomberg Link
- Video: Dr. West's video updates on BioTime's YouTube channel, September 8, 2013
- Video: Dr. West of BioTime interviewed on CNBC's "Squawk on the Street" December 8, 2009
- Audio: Dr. West interviewed on Bloomberg Radio's "The Hays Advantage" February 11, 2010
- Video: Dr. West interviewed as part of panel on "TSN: The Science Network," along with Stephanie Lederman of the American Federation for Aging Research and Mark Collins of the Glenn Foundation for Medical Research, June 15, 2011
- Video: Dr. West's presentation at 2009 Longevity Summit, from the Manhattan Beach Project
- Video: The Stem Cell Controversy January 18, 2006, Woodrow Wilson Center event featuring Robin Cook (novelist), William B. Hurlbut, and Michael D. West
- The Prospects of Human Life Extension recorded November 2004 at the Long Now Foundation[dead link]
- Therapeutic Cloning Under Fire: An Interview with Michael D. West, PhD, cover story, Life Extension Magazine, March 2002
- Interview of Michael West on new breakthroughs in anti-aging cloning research, by Life Extension Magazine, March 18, 2000