Michael Huff was selected in the 1st round (7th overall) by the Oakland Raiders in the 2006 NFL Draft. After immediately being named the starter at strong safety in his rookie year, he recorded 78 tackles. On October 22, 2006, in a game against the Arizona Cardinals, Huff recorded 4 solo tackles and his first safety. He started all 16 games in his rookie season.
His first forced fumble came in his second year in a match-up against the Houston Texans on November 11, 2007. His first interception came in a game against rivalry team Kansas City Chiefs, which set up kickerSebastian Janikowski for the field goal, which lead to a victory 20-17. Huff ended the game with an impressive performance, adding in 9 total tackles (7 solo, 2 assists). The following week, against another rivalry team, the Denver Broncos, Huff sacked Broncos QuarterbackJay Cutler. Huff finished his 2007 season with 85 tackles, 1 forced fumble and 1 interception.
At the start of the 2009 season, Oakland had Hiram Eugene and Huff splitting snaps. Huff displayed excellent ball skills in the first two weeks, intercepting 3 passes. Huff finished the season with 59 tackles, half a sack and 3 interceptions, playing next to strong safetyTyvon Branch.
Huff opened the 2010 season as the Raiders starting free safety, still playing next to Tyvon Branch. The 2010 season would be the Raiders best season at 8-8 since losing Super Bowl XXXVII to the Tampa Bay Buccaneers in the 2002 NFL season. For the second straight year, Huff finished with 3 interceptions, along with career highs in almost every defensive category on his way to his first All-Pro section, he was selected as a 2nd team All-Pro. Huff finished the season with 94 tackles, 4 sacks, 3 forced fumbles, and 3 interceptions.