Michael Stuart Brown

From Wikipedia, the free encyclopedia
  (Redirected from Michael S. Brown)
Jump to navigation Jump to search
Michael Brown
Mike Brown 2003.jpg
Michael Stuart Brown

(1941-04-13) April 13, 1941 (age 81)
Brooklyn, New York, United States
Alma mater
Known forRegulation of cholesterol metabolism
Alice Lapin
(m. 1964)
[citation needed]
Childrentwo[citation needed]
Scientific career

Michael Stuart Brown ForMemRS (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism.[2][3][4][5]

Education and early life[edit]

Brown was born in Brooklyn, New York, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman.[4][6] He graduated from Cheltenham High School (Wyncote, Pennsylvania). Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966.

Career and research[edit]

Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - receptor-mediated endocytosis.

Their findings led to the development of statin drugs, the cholesterol-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States.[citation needed] Their discoveries are improving more lives every year, both in the US and around the world.[citation needed] New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein prenylation) in cancer. In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L. Goldstein (co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received the National Medal of Science for his contributions to medicine.

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the sterol regulatory element binding proteins (SREBPs). Since 1993, Drs. Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.

Dr. Brown holds the W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine. Frequently mentioned as a candidate for nationally-prominent positions in scientific administration, Dr. Brown, like his colleague Joseph L. Goldstein, elects to continue hands-on involvement with research, leading a research team that typically includes a dozen doctoral and postdoctoral trainees. He and his colleague are among the most highly cited scientists in the world.[citation needed]

Brown is also on the prestigious Prix Galien USA Committee that "recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines". The inauguration of the Prix Galien in the US, the equivalent of the Nobel Prize in this field, was in September 2007, and the winners were selected by a preeminent scientific and learned committee that included seven Nobel laureates, of which Brown was one.

Awards and honors[edit]

Brown has won numerous awards and honors, including:



  1. ^ a b "Professor Michael Brown ForMemRS". London: Royal Society. Archived from the original on 2015-11-06.
  2. ^ "Biography: Michael S. Brown". The Notable Names Database. Soylent Communications. 2008. Retrieved 2008-06-15.
  3. ^ "Michael Brown - Nobel Prize Inspiration Initiative". Nobelprizeii.org. Retrieved 2015-11-06.
  4. ^ a b "Michael S. Brown - Biographical". Nobelprize.org. 1941-04-13. Retrieved 2015-11-06.
  5. ^ "Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis". Nobelprize.org. 1985-12-08. Retrieved 2015-11-06.
  6. ^ "BROWN (Brown), Michael, photo, biography". Persona.rin.ru. 1941-04-13. Retrieved 2015-11-06.
  7. ^ "Earl and Thressa Stadtman Distinguished Scientist Award". Asbmb.org. Retrieved 2015-11-06.
  8. ^ "University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award". Research!America. 2007-03-21. Retrieved 2015-11-06.
  9. ^ [1] Archived October 8, 2013, at the Wayback Machine
  10. ^ "Herbert Tabor Research Award". Asbmb.org. Retrieved 2015-11-06.
  11. ^ "Albany Medical College: 2003". Amc.edu. 2015-08-14. Retrieved 2015-11-06.
  12. ^ Daniel W. Foster; Jean D. Wilson. "Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown" (PDF). Jci.org. Retrieved 2015-11-06.
  13. ^ [2] Archived April 10, 2012, at the Wayback Machine
  14. ^ https://search.amphilsoc.org/memhist/search?creator=Michael+S.+Brown&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced. {{cite web}}: Missing or empty |title= (help)
  15. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  16. ^ "1985 Basic Medical Research Award". The Lasker Foundation. 2007-09-16. Archived from the original on 2015-09-13. Retrieved 2015-11-06.
  17. ^ "Past ASHG Award Recipients". ASHG. Archived from the original on 2014-10-03. Retrieved 2015-11-06.
  18. ^ "Joseph L. Goldstein". Gairdner. Retrieved 2015-11-06.
  19. ^ https://www.amacad.org/person/michael-stuart-brown. {{cite web}}: Missing or empty |title= (help)
  20. ^ http://www.nasonline.org, National Academy of Sciences -. "Michael Brown". www.nasonline.org. Retrieved 23 March 2018. {{cite web}}: External link in |last= (help)
  21. ^ "Richard Lounsbery Award". Nasonline.org. Retrieved 2015-11-06.
  22. ^ [3] Archived October 7, 2012, at the Wayback Machine
  23. ^ "Pfizer Award in Enzyme Chemistry". Divbiolchem.org. Retrieved 2015-11-06.

External links[edit]