|Date of birth||10 March 1970|
|Place of birth||Venice, Italy|
|Height||1.78 m (5 ft 10 in)|
|* Senior club appearances and goals counted for the domestic league only.
Serena started his playing career with Mestre of Serie C2, then become Venezia following a merger. He was signed by Juventus in 1989, and made four league appearances with the bianconeri. He then played for Monza and Verona on single season loans, before signing for Sampdoria in 1992, where he played for three years. In 1995 he was signed by Fiorentina, and in 1998 by La Liga club Atlético Madrid, where he made 35 appearances with 3 goals during his only season with the club. During his time with the Spanish club, he gained a spot in the national team, making his one and only appearance with the azzurri on 5 September 1998, in a 2–0 away win to Wales, under Dino Zoff. He then returned to Italy the following season to play for Parma, making 15 league appearances, but moved on to Inter soon after, during the winter transfer market (in an exchange with Paulo Sousa). With the nerazzurri jersey, he made only 25 appearances in three seasons, mainly because of the several injuries he experienced during his years at Inter, which forced him to retire in 2003.
In 2007 he became the Venezia youth team coach, also getting involved in obtaining a coaching licence. On 11 March 2008 he was unveiled as new Venezia head coach, replacing Salvo D'Adderio. He was sacked a few months later, on 11 November, due to poor results. He was recalled on February 2009, with Venezia placed in the league bottom, and managed to bring his club out of the relegation zone.
This attracted interest from Serie B club Mantova, who appointed him as new boss for the 2009–10 season. Mantova finished 3rd bottom of Serie B and were relegated. However, due to financial difficulties, their entry to Lega Pro Prima Divisione was rejected and the club folded.
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- Serena Timossi (10 March 2010). "Michele Serena, la forza dell'umiltà" (in Italian). Sampdoria News. Retrieved 12 November 2015.
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- (Italian) UFFICIALE: Spezia, Michele Serena nuovo allenatore TuttoMercatoWeb
- (Italian) UFFICIALE: Padova, Michele Serena è il nuovo allenatore TuttoMercatoWeb
- "Michele Serena" (in French). Yahoo. Retrieved 12 November 2015.