Microsomal triglyceride transfer protein

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MTTP
Identifiers
Aliases MTTP, ABL, MTP, Microsomal triglyceride transfer protein
External IDs MGI: 106926 HomoloGene: 212 GeneCards: MTTP
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MTTP
Genomic location for MTTP
Band 4q23 Start 99,563,761 bp[1]
End 99,623,999 bp[1]
RNA expression pattern
PBB GE MTTP 205675 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300785
NM_000253

NM_001163457
NM_008642
NM_001355051
NM_001355052

RefSeq (protein)

NP_000244
NP_001287714

NP_001156929
NP_032668
NP_001341980
NP_001341981

Location (UCSC) Chr 4: 99.56 – 99.62 Mb Chr 4: 138.09 – 138.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[5][6]

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[6]

Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

Pharmacology[edit]

Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138823 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028158 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet. 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381. 
  6. ^ a b "Entrez Gene: MTTP microsomal triglyceride transfer protein". 

Further reading[edit]