Mihalis Papayiannakis (Greek: Μιχάλης Παπαγιαννάκης; 19 August 1941 – 26 May 2009) was a Greek politician. He was born in Kalamata; his father was executed by the Nazis during World War II. He died on May 26, 2009 after a long battle with cancer.
He taught at Panthéon-Assas University, the Institute of Business Management at Orsay and the Mediterranean Agronomical Institute at Montpellier (IAMM). From 1967 to 1987, his research areas included the Mediterranean economy, the European Community, the Chinese agricultural industry, and fishing. He was a contributor to several newspapers and magazines.
At first a member of United Democratic Left until 1963. From 1967 to 1973, he was a member of the anti-junta Democratic Defence. In 1987, he was a founding member of the Greek Left, which later became Synaspismos.