Going undrafted into the NFL in 1997, Mike Flynn was first signed by the Baltimore Ravens, who released him. Flynn was then picked up by the Tampa Bay Buccaneers and Jacksonville Jaguars. Resigned by Baltimore, Flynn didn't make his debut until 1998. Two years later, the Ravens won Super Bowl XXXV with Flynn as the starting right guard. When center Jeff Mitchell signed elsewhere, Flynn shifted to center and played there for the Ravens through 2007. Picked up by the New England Patriots in 2008, Flynn was released before the season.
Flynn co-hosts a radio show on weekends with Ryan Johnston called "Johnston and Flynn" on 98.5 The Sports Hub in Boston. Flynn also joins "The Toucher and Rich Show" on Mondays both on 98.5 The Sports Hub in Boston during the football season.