While playing for Western Illinois, Scifres was the only punter from NCAA Div 1-AA (now called the Football Championship Division) to become a 2002 finalist of the Ray Guy Award, given to the nation's top punter. He set a school and conference record with an 89-yard punt against Southwest Missouri State in 2000. Scifres also kicked a game-winning 56-yard field goal in his first career attempt in 1999. Two-time First-team All-American selection by Football Gazette, Three-time All-conference selection, Seven-time National player of the week, and Five-time Conference player of the week. His college nickname was Scabies. He graduated from Western Illinois University with a degree in Communications & Broadcasting.
In the Chargers' 2009 Wild Card Playoff versus the Colts, Scifres kicked a 67-yard punt and averaged 51.7 yards with six punts. Also, all his punts during the game were inside the Chargers' own 20-yard line, with 4 inside their 10-yard line. Perhap Scifres's best punt of the game was the last, a 52-yard kick launched from the San Diego 47 yard line that bounced out of bounds at the Colts' 1, pinning Indianapolis deep and allowing the Chargers' defense to force the Colts to punt the ball away from the back of their own end zone. Scifres said after the game, "I don't know if you can dream a game like this."  Scifres also made some clutch punts near the end of the 2007 Charger's AFC Divisional Playoff Game that pinned the Colts back deep in their own territory and ultimately helped thwart the Colts' QB Peyton Manning's come back attempts. In week 11 vs the Denver Broncos Scifres completed his first NFL completion to Mike Tolbert for 28 yards.
Scifres boomed his way into the Chargers’ record books in 2012. Already the team’s record-holder for career punting average (45.3), Scifres was voted the team’s Special Teams Player of the Year last season after setting a new team record with an average of 48.3 yards per punt, a mark that shattered the previous high of 46.7, which he set back in 2010. And thanks to the Chargers’ outstanding coverage units, Scifres posted a 40.6-yard net average in 2012, second in the franchise’s 53-year history.
In 2014, U-T San Diego wrote that Scifres "arguably was the team MVP" in a Week 11 win over the Oakland Raiders after he landed punts on the Raiders' own 2-, 4-, 6-, 8- and 12-yard line. In a 23–14 loss in Week 14 to the New England Patriots, he suffered a clavicle fracture on a blocked punt, when his body was twisted mid-air and his shoulder landed hard on the ground. The Chargers placed him on injured reserve after he had season-ending surgery.