Miles Mosley was trained in classical music and jazz at Colburn School of Music in downtown L.A. Mosley has studied with some of jazz's finest musicians, including John Clayton, Ray Brown and Al McKibbon. He claims he picked the upright bass because it was the only instrument at his school that he did not have to bring home with him. Mosley's style has often been described as brothel jazz; Mosley himself describes it as if Jimi Hendrix played upright bass in Prince's band.
Mosley has released a number of albums containing his own solo work. In addition, he has worked for Creative Counseling Network, a non-profit organization that provides access to the arts for under-served young people.