Carduus marianus L.
Silybum marianum has other common names include cardus marianus, milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle. This species is an annual or biennial plant of the Asteraceae family. This fairly typical thistle has red to purple flowers and shiny pale green leaves with white veins. Originally a native of Southern Europe through to Asia, it is now found throughout the world.
It grows 30 to 200 cm tall, having an overall conical shape with an approx. 160 cm max. diameter base. The stem is grooved and more or less cottony. With the largest specimens the stem is hollow.
The leaves are oblong to lanceolate. They are either lobate or pinnate, with spiny edges. They are hairless, shiny green, with milk-white veins.
The flower heads are 4 to 12 cm long and wide, of red-purple colour. They flower from June to August in the North or December to February in the Southern Hemisphere ( Summer through Autumn ).
The bracts are hairless, with triangular, spine-edged appendages, tipped with a stout yellow spine.
Distribution and habitat
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Possibly native near the coast of southeast England, it has been widely introduced outside its natural range, for example into North America, Iran, Australia and New Zealand where it is considered an invasive weed. Cultivated fields for the production of raw material for the pharmaceutical industry exist on a larger scale in Austria (Waldviertel region), Germany, Hungary, Poland, China and Argentina. In Europe it is sown yearly in March–April. The harvest in two steps (cutting and threshing) takes place in August, about 2–3 weeks after the flowering.
Milk thistle (Silybum marianum) is a thorny plant presenting decorative leaves with a white pattern of veins and purple flower heads. The plant originates from mountains of the Mediterranean region, where it forms scrub on a rocky base.
The plant is sometimes also used as a decorative element in gardens, and its dried flower heads may be used for the decoration of dry bouquets.
Traditional milk thistle extract is made from the seeds, which contain approximately 4–6% silymarin. The extract consists of about 65–80% silymarin (a flavonolignan complex) and 20–35% fatty acids, including linoleic acid. Silymarin is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin) and one flavonoid (taxifolin). Silibinin, a semipurified fraction of silymarin, is primarily a mixture of 2 diastereoisomers, silybin A and silybin B, in a roughly 1: 1 ratio.
Milk thistle has been used for a number of purposes including liver disease, and cancer; however, clinical studies are largely heterogeneous and contradictory.
In trials, silymarin has typically been administered in amounts ranging from 420–480 mg per day in two to three divided doses. However, higher doses have been studied, such as 600 mg daily in the treatment of type II diabetes (with significant results), and 600 or 1200 mg daily in patients chronically infected with hepatitis C virus  (without significant results). An optimal dosage for milk thistle preparations has not been established.
Herbal medicinal research
Silybum marianum is used in traditional Chinese medicine to clear heat and relieve toxic material, to soothe the liver and to promote bile flow. Though its efficacy in treating diseases is still unknown, Silybum marianum is sometimes prescribed by herbalists to help treat liver diseases (cirrhosis, jaundice and hepatitis). Both in vitro and animal research suggest that Silibinin (syn. silybin, sylimarin I) may have hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.
A 2000 study of such claims by the AHRQ concluded that "clinical efficacy of milk thistle is not clearly established". A 2005 Cochrane Review considered thirteen randomized clinical trials which assessed milk thistle in 915 patients with alcoholic and/or hepatitis B or C virus liver diseases. They question the beneficial effects of milk thistle for patients with alcoholic and/or hepatitis B or C virus liver diseases and highlight the lack of high-quality evidence to support this intervention. Cochrane concluded that more good quality randomized clinical trials on milk thistle versus placebo are needed.
Milk thistle extracts are known to be safe and well tolerated. Milk thistle supplements, however, were measured to have the highest mycotoxin concentrations of up to 37 mg/kg when compared amongst various plant-based dietary supplements.
Use as food
Milk thistle has also been known to be used as food. The roots can be eaten raw or boiled and buttered or par-boiled and roasted. The young shoots in spring can be cut down to the root and boiled and buttered. The spiny bracts on the flower head were eaten in the past like globe artichoke, and the stems (after peeling) can be soaked overnight to remove bitterness and then stewed. The leaves can be trimmed of prickles and boiled and make a good spinach substitute or they can also be added raw to salads.
Because of potassium nitrate content, the plant has been found to be toxic to cattle and sheep. When potassium nitrate is eaten by ruminants, the bacteria in an animal's stomach breaks the chemical down, producing nitrite ions. Nitrite ions then combine with hemoglobin to produce methaemoglobin, blocking the transport of oxygen. The result is a form of oxygen deprivation.
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- Rambaldi A, Jacobs BP, Gluud C (2007). "Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases". The Cochrane Database of Systematic Reviews (4): CD003620. doi:10.1002/14651858.CD003620.pub3. PMID 17943794.
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- Tamayo C, Diamond S (2007). "Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.)" (PDF). Integrative Cancer Therapies 6 (2): 146–57. doi:10.1177/1534735407301942. PMID 17548793. Retrieved 2016-01-03.
Milk thistle extracts are known to be safe and well tolerated, and toxic or adverse effects observed in the reviewed clinical trials seem to be minimal.
- Veprikova Z, Zachariasova M, Dzuman Z, Zachariasova A, Fenclova M, Slavikova P, Vaclavikova M, Mastovska K, Hengst D, Hajslova J (2015). "Mycotoxins in Plant-Based Dietary Supplements: Hidden Health Risk for Consumers". Journal of Agricultural and Food Chemistry 63 (29): 6633–43. doi:10.1021/acs.jafc.5b02105. PMID 26168136. Retrieved 2016-01-03.
The highest mycotoxin concentrations were found in milk thistle-based supplements (up to 37 mg/kg in the sum).
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- Rambaldi, Andrea; Jacobs, Bradly P; Gluud, Christian (2007). Rambaldi, Andrea, ed. "Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases". Cochrane Database of Systematic Reviews (4): CD003620. doi:10.1002/14651858.CD003620.pub3. PMID 17943794.
- UC Davis profile
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