Mindanao Avenue is an 8–10 lane divided avenue connecting EDSA and NLEX and is a part of Circumferential Road 5 (C-5) in Metro Manila, Philippines. It is one of the three parallel roads that connects Tandang Sora and Congressional Avenues (Visayas Avenue and Luzon Avenue were the others); that is why it was named after the southernmost mainland of the Philippines, Mindanao. It used to be a 2 km highway connecting North Avenue and Congressional Avenue, but as a part of the C-5 projects, Mindanao Avenue was extended to EDSA in the south and to Quirino Highway to the north. The new roads opened in 2000.
Another road also named Mindanao Avenue starts at Commonwealth Avenue and terminates at a dead end at School of Saint Anthony, Novaliches, Quezon City. That road is not in any way connected to the original Mindanao Avenue but was planned to be the one and the same road in the original plan for Quezon City.
Mindanao Avenue replaced some segments of Tandang Sora Avenue belonging to C-5. (Tandang Sora has no access to NLEX) The Mindanao Avenue-NLEX road began construction afterwards. This segment became an expressway after its construction finished.