Minichromosome maintenance

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MCM2/3/5 family
PDB 1ltl EBI.jpg
Structure of MCM from archaeal M. Thermoautotrophicum.[1]
Symbol MCM
Pfam PF00493
Pfam clan CL0023
InterPro IPR001208
Potential role of Cdc6 at the initiation of DNA replication.[2]

Minichromosome maintenance protein complex (MCM) is a eukaryotic DNA helicase complex required for the process of DNA replication, specifically the formation and elongation of the replication fork. It is a hexamer of six related polypeptides (MCM2 through MCM7) that form a ring structure.[3][4][5] MCM is a component of the pre-replication complex that forms at the eukryotic origin of replication.

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  1. ^ Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS (March 2003). "The structure and function of MCM from archaeal M. Thermoautotrophicum". Nat. Struct. Biol. 10 (3): 160–7. doi:10.1038/nsb893. PMID 12548282. 
  2. ^ Borlado LR, Méndez J (February 2008). "CDC6: from DNA replication to cell cycle checkpoints and oncogenesis". Carcinogenesis 29 (2): 237–43. doi:10.1093/carcin/bgm268. PMID 18048387. 
  3. ^ a b Cortez D, Glick G, Elledge SJ (July 2004). "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. doi:10.1073/pnas.0403410101. PMC 454167. PMID 15210935. 
  4. ^ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). "Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus". J. Biol. Chem. 277 (14): 12118–27. doi:10.1074/jbc.M200091200. PMID 11821426. 
  5. ^ Brewster, Aaron; Chen, Xiaojiang (June 2010). "Insights into MCM functional mechanism: lessons learned from the archaeal MCM complex". Crit Rev Biochem Mol Biol 45 (3): 243–256. doi:10.3109/10409238.2010.484836. PMC 2953368. PMID 20441442. 

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