Miotine

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Miotine
Miotine.png
Names
IUPAC name
[3-[1-(Dimethylamino)ethyl]phenyl] N-methylcarbamate
Identifiers
4464-16-8 YesY
ChemSpider 41955 N
Jmol-3D images Image
KEGG C11763 N
PubChem 46093
Properties
C12H18N2O2
Molar mass 222.29 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.[1]

Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects.[2]

Miotine equilibrium

References[edit]

  1. ^ "http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/2002_Bar-On_Biochem.pdf"
  2. ^ "http://media.wiley.com/product_data/excerpt/72/04700259/0470025972.pdf"