mir-101 microRNA precursor family

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mir-101 microRNA precursor family
Symbol mir-101
Rfam RF00253
miRBase MI0000103
miRBase family MIPF0000046
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739[permanent dead link])[1] and mouse (MI0000148).[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.

Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]


  1. ^ Mourelatos, Z; Dostie J; Paushkin S; Sharma A; Charroux B; Abel L; Rappsilber J; Mann M; Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365Freely accessible. PMID 11914277. 
  2. ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417. 
  3. ^ Lánczky, András; Nagy, Ádám; Bottai, Giulia; Munkácsy, Gyöngyi; Szabó, András; Santarpia, Libero; Győrffy, Balázs (2016-12-01). "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment. 160 (3): 439–446. doi:10.1007/s10549-016-4013-7. ISSN 1573-7217. PMID 27744485. 

Further reading[edit]

  • He, XP; Shao, Y; Li, XL; Xu, W; Chen, GS; Sun, HH; Xu, HC; Xu, X; Tang, D; Zheng, XF; Xue, YP; Huang, GC; Sun, WH (November 2012). "Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth". The FEBS Journal. 279 (22): 4201–12. doi:10.1111/febs.12013. PMID 23013439. 

External links[edit]