mir-124 microRNA precursor family

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miR-124 microRNA precursor family
RF00239.jpg
Identifiers
Symbol mir-124
Rfam RF00239
miRBase MI0000443
miRBase family MIPF0000021
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373),[1] nematode worms (MI0000302),[2] mouse (MI0000150) and human (MI0000443).[3] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.[4] However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.[5]

Targets of miR-124[edit]

  • Visvanathan et al.. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).[6]
  • Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.[7]
  • Arrant et al. wrote that miR-124 changes glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia.[8]

References[edit]

  1. ^ Lai, EC; Tomancak P; Williams RW; Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biol. 4 (7): R42–. PMC 193629Freely accessible. PMID 12844358. doi:10.1186/gb-2003-4-7-r42. 
  2. ^ Lim, LP; Lau NC; Weinstein EG; Abdelhakim A; Yekta S; Rhoades MW; Burge CB; Bartel DP (2003). "The microRNAs of Caenorhabditis elegans". Genes Dev. 17 (8): 991–1008. PMC 196042Freely accessible. PMID 12672692. doi:10.1101/gad.1074403. 
  3. ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. PMID 12007417. doi:10.1016/S0960-9822(02)00809-6. 
  4. ^ Cao X, Pfaff SL, Gage FH (2007). "A functional study of miR-124 in the developing neural tube". Genes Dev. 21 (5): 531–6. PMC 1820895Freely accessible. PMID 17344415. doi:10.1101/gad.1519207. 
  5. ^ Yoo AS, Staahl BT, Chen L, Crabtree GR (2009). "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development". Nature. 460 (7255): 642–6. PMC 2921580Freely accessible. PMID 19561591. doi:10.1038/nature08139. 
  6. ^ Visvanathan J, Lee S, Lee B, Lee JW, Lee SK (2007). "The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development". Genes Dev. 21 (7): 744–9. PMC 1838526Freely accessible. PMID 17403776. doi:10.1101/gad.1519107. 
  7. ^ Makeyev EV, Zhang J, Carrasco MA, Maniatis T (August 2007). "The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing". Mol. Cell. 27 (3): 435–48. PMC 3139456Freely accessible. PMID 17679093. doi:10.1016/j.molcel.2007.07.015. 
  8. ^ Roberson, Erik (4 December 2014). "MicroRNA-124 modulates social behavior in frontotemporal dementia". Nature Medicine. doi:10.1038/nm.3768. Retrieved 5 December 2014. 

External links[edit]