miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies ( MI0000373),  nematode worms ( MI0000302), mouse (  MI0000150) and human ( MI0000443). The mature ~21  nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation. However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.  
Targets of miR-124 [ edit ]
et al.. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).  Makeyev et al. showed that miR-124 directly targets
PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.  Arrant et al. wrote that miR-124 changes
glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia. 
References [ edit ]
^ Lai, EC; Tomancak P; Williams RW; Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biol. 4 (7): R42–. PMC . 193629 PMID 12844358. doi: 10.1186/gb-2003-4-7-r42.
^ Lim, LP; Lau NC; Weinstein EG; Abdelhakim A; Yekta S; Rhoades MW; Burge CB; Bartel DP (2003). "The microRNAs of Caenorhabditis elegans". Genes Dev. 17 (8): 991–1008. PMC . 196042 PMID 12672692. doi: 10.1101/gad.1074403.
^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. PMID 12007417. doi: 10.1016/S0960-9822(02)00809-6.
^ Cao X, Pfaff SL, Gage FH (2007). "A functional study of miR-124 in the developing neural tube". Genes Dev. 21 (5): 531–6. PMC . 1820895 PMID 17344415. doi: 10.1101/gad.1519207.
^ Yoo AS, Staahl BT, Chen L, Crabtree GR (2009). "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development". Nature. 460 (7255): 642–6. PMC . 2921580 PMID 19561591. doi: 10.1038/nature08139.
^ Visvanathan J, Lee S, Lee B, Lee JW, Lee SK (2007). "The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development". Genes Dev. 21 (7): 744–9. PMC . 1838526 PMID 17403776. doi: 10.1101/gad.1519107.
^ Makeyev EV, Zhang J, Carrasco MA, Maniatis T (August 2007). "The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing". Mol. Cell. 27 (3): 435–48. PMC . 3139456 PMID 17679093. doi: 10.1016/j.molcel.2007.07.015.
^ Roberson, Erik (4 December 2014). "MicroRNA-124 modulates social behavior in frontotemporal dementia". . Nature Medicine doi: 10.1038/nm.3768 . Retrieved . 5 December 2014
External links [ edit ]