mir-130 microRNA precursor family

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mir-130 microRNA precursor family
RF00258.jpg
Identifiers
Symbol mir-130
Rfam RF00258
miRBase MI0000448
miRBase family MIPF0000034
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408[permanent dead link]),[1] and in human (MI0000448, MI0000748[permanent dead link]).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4]

References[edit]

  1. ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417. 
  2. ^ Houbaviy, HB; Murray MF; Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell. 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684. 
  3. ^ Kutay H, Bai S, Datta J, et al. (2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". J. Cell. Biochem. 99 (3): 671–8. doi:10.1002/jcb.20982. PMC 3033198Freely accessible. PMID 16924677. 
  4. ^ Escobar G, Moi D, Ranghetti A, et al. (Jan 2014). "Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression". Sci Transl Med. 6 (217): 217. doi:10.1126/scitranslmed.3006353. PMID 24382895. 

External links[edit]