mir-145

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MIR145
Identifiers
Aliases MIR145, microRNA 145, MIRN145, miR-145, miRNA145
External IDs GeneCards: 406937
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC) Chr 5: 149.43 – 149.43 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human
mir-145
RF00675.png
Conserved secondary structure of mir-145
Identifiers
Symbol mir-145
Rfam RF00675
miRBase family MIPF0000079
Other data
RNA type microRNA
Domain(s) Eukaryota;

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[1]

Targets[edit]

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin.[2] Larsson et al.[3] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[4]

Role in cancer[edit]

miR-145 is hypothesised to be a tumor suppressor.[5] miR-145 has been shown to be down-regulated in breast cancer.[2] miR-145 is also involved in colon cancer [4][6][7] and acute myeloid leukemia.[8]

References[edit]

  1. ^ "Entrez Gene: MicroRNA 145". Retrieved 2015-01-26. 
  2. ^ a b Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene 29 (50): 6569–80. doi:10.1038/onc.2010.386. PMID 20818426. 
  3. ^ Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099. 
  4. ^ a b Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer 117 (1): 86–95. doi:10.1002/cncr.25522. PMC 2995010. PMID 20737575. 
  5. ^ Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America 106 (9): 3207–12. doi:10.1073/pnas.0808042106. PMC 2651330. PMID 19202062. 
  6. ^ Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology 72 (5-6): 397–402. doi:10.1159/000113489. PMID 18196926. 
  7. ^ Mazza, Tommaso; Mazzoccoli, Gianluigi; Fusilli, Caterina; Capocefalo, Daniele; Panza, Anna; Biagini, Tommaso; Castellana, Stefano; Gentile, Annamaria; De Cata, Angelo (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research 44 (9): 4025–4036. doi:10.1093/nar/gkw245. ISSN 1362-4962. PMC 4872111. PMID 27067546. 
  8. ^ Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood 117 (2): 595–607. doi:10.1182/blood-2010-03-277012. PMID 20962326. 

Further reading[edit]

External links[edit]