mir-148/mir-152 microRNA precursor family

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mir-148/mir-152 microRNA precursor family
RF00248.jpg
Identifiers
Symbol mir-148
Rfam RF00248
miRBase MI0000253
miRBase family MIPF0000056
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

In molecular biology, miR-148 is a microRNA whose expression has been demonstrated in human (MI0000253[permanent dead link]), mouse (MI0000550), rat (MI0000616[permanent dead link]) and zebrafish (MI0002015).[1][2][3] miR-148 has also been predicted in chicken (MI0001189).

These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse (MI0000174[permanent dead link]) and is predicted in human (MI0000462[permanent dead link]).[1]

The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 3' arm of the hairpin.

Targets of miR-148[edit]

MicroRNAs act by lowering the expression of genes by binding to target sites in the 3' UTR of the mRNAs. However recently it was shown by Duursma and colleagues that miR-148 down regulates Dnmt3b by binding to a region in the protein coding region.[4]

References[edit]

  1. ^ a b Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417. 
  2. ^ Kim, J; Krichevsky A; Grad Y; Hayes GD; Kosik KS; Church GM; Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA. 101 (1): 360–365. Bibcode:2003PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190Freely accessible. PMID 14691248. 
  3. ^ Chen, PY; Manninga H; Slanchev K; Chien M; Russo JJ; Ju J; Sheridan R; John B; Marks DS; Gaidatzis D; Sander C; Zavolan M; Tuschl T (2005). "The developmental miRNA profiles of zebrafish as determined by small RNA cloning". Genes Dev. 19 (11): 1288–1293. doi:10.1101/gad.1310605. PMC 1142552Freely accessible. PMID 15937218. 
  4. ^ Duursma AM, Kedde M, Schrier M, le Sage C, Agami R (May 2008). "miR-148 targets human DNMT3b protein coding region". RNA. 14 (5): 872–7. doi:10.1261/rna.972008. PMC 2327368Freely accessible. PMID 18367714. 

External links[edit]